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  Back to Chat The Benefits of TrialNet

Registered User Moderator   (server) Tue Feb 22 08:50:00 PM EST 2011
Our chat about the Benefits of Participating in TrialNet with Dr. Carla Greenbaum starts in 10 min in the 'TrialNet' room.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:00:50 PM EST 2011
Welcome to everyone. This is my first experience in a "chat room", so let me know if there are any problems.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:01:35 PM EST 2011
I am logged on to tell you about Diabetes TrialNet and answer questions or concerns you may have.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:02:26 PM EST 2011
Hi Dr. Greenbaum. Usually, people just pop in and start talking.

I will start off with asking: who should participate in TrialNet and why?

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:02:40 PM EST 2011
Welcome Dr. Greenbaum. You're coming through loud and clear. LOL

Registered User Billetdeaux CWD Programs, Sam's mom, dx'd 8/98  (76.226.135.19) Tue Feb 22 09:03:01 PM EST 2011
Good evening! Thank you for being with us. Not sure how many will join this evening, but certainly there will be hundreds who read the transcript... so perhaps you could begin by giving an overview of TrialNet Studies and why it is so important to participate.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:04:23 PM EST 2011
Hi Brenda,
thanks for your question. TrialNet is a international diabetes research group that is funded by your tax dollars! the goal is to find ways to stop the beta cells (insulin producing cells) from being destroyed

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:05:00 PM EST 2011
If we can stop the beta cells from being destroyed BEFORE people get diabetes, then we will be preventing the disease

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:05:31 PM EST 2011
If we can stop the beta cells from being destroyed soon AFTER people get diabetes, then we can make diabetes easier to treat

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:06:06 PM EST 2011
So, this is why you ask for siblings/children of those with type 1 to participate? They have a greater risk of developing the disease as I understand it.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:06:07 PM EST 2011
And importantly, if we can stop the beta cell from being destroyed years after people have diabetes, that will allow them to get new beta cells someday

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:06:42 PM EST 2011
If you have a family member with type 1 diabetes, the risk of getting type 1 diabetes ix 15X MORE than if you have no family member with the disease

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:07:10 PM EST 2011
So, the people that should be tested for this study are those that have a family member with diabetes.

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:07:42 PM EST 2011
Do you find there to be cases where it was difficult for parents to think about having their other children screened? I've thought that having another child test positive was like waiting for the other shoe to fall.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:07:44 PM EST 2011
That includes first degree relatives (a) siblings (b) parents (c) children of individuals with diabetes

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:07:51 PM EST 2011
Our kids are/were part of DAISY out of the U. of CO. Is that similar? Blood drawn in Nov. was neg for antibodies/celiac in our two non-D children.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:08:18 PM EST 2011
It also means that SECOND degree relatives should be tested as well. That means cousins, neices, nephews, and grandchildren of people with type 1 diabetes

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:08:58 PM EST 2011
Hi Brenda,
It is a good question about whether people who have been in DAISY or other studies should still be in TrialNet. The answer is YES.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:09:48 PM EST 2011
The reason is that TrialNet is testing for the signs that the immune system is attacking the beta cells. We test for antibodies. Studies in newborns test first for GENES. People without high risk genes can still get diabetes

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:11:14 PM EST 2011
Hmm, maybe should have them re-screened through you. I will think about it. They are now 20 and 16 years old.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:11:31 PM EST 2011
Hi Scott,
Your question is also a good one. But, being involved in research if you have another child is at risk for disease for many people can be empowering. Moreover, by being in the study your child MAY be eligible for prevention studies to delay the disease

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:12:52 PM EST 2011
Where can someone get screened?

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:13:16 PM EST 2011
Another point for being in the study and finding that another family is at risk is that just by being in the study, you will be closely followed. Thus, if diabetes occurs, it will be found very early...before the child feels sick.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:13:25 PM EST 2011
Can your child test positive for antibodies today, negative in a year? What does that mean?

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:13:44 PM EST 2011
Scott--usually at FFL (another reason you need to attend! LOL).

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:14:11 PM EST 2011
I'm not the one who needs convincing Brenda!

Registered User Billetdeaux CWD Programs, Sam's mom, dx'd 8/98  (76.226.135.19) Tue Feb 22 09:14:44 PM EST 2011
TrialNet meets with families at Friends for Life (Orlando, Toronto, and UK). You can sign up ahead of time - the info will be posted online on the conference webpages. Smile 

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:14:46 PM EST 2011
The good news is that people can get screened wherever they live in North America. There are more than 300 Trialnet sites that can do the screening. However, if you dont live near a site, we can send a "test kit" and the blood can be drawn at your local lab or doctor's office and shipped to TrialNet.

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:15:38 PM EST 2011
Good. I am going to make a point of mentioning that at our next support group meeting.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:16:04 PM EST 2011
Is it a fingerprick or tube of blood?

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:16:34 PM EST 2011
If more than one antibody is found, it is very unlikely that these markers of the immune system will be negative later. Someone with only one antibody may have some variations in the test, but TrialNet investigators can explain the individual results in detail with participants.

Registered User Billetdeaux CWD Programs, Sam's mom, dx'd 8/98  (76.226.135.19) Tue Feb 22 09:16:36 PM EST 2011
To go back to Brenda's question... how many years is an appropriate amount of time in between screenings? I've aged out  Rolling Eyes  but my daughter hasn't. She's 23 - was tested over 5 years ago.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:17:34 PM EST 2011
Brenda,
Great question! We current use a tube of blood since the tests are much more accurate that way. We are exploring tests by fingerprick, but recall, this will need more blood than a current glucometer strip...so, we aren't really ready for this yet.

Registered User Billetdeaux CWD Programs, Sam's mom, dx'd 8/98  (76.226.135.19) Tue Feb 22 09:19:10 PM EST 2011
Another question - let's say someone tests positive for antibodies... is there a way to channel the family into potential studies that will help research and may in fact help the child?

Registered User NomadIvy Mom to 4, K dx'd 04/10  (114.185.101.152) Tue Feb 22 09:19:51 PM EST 2011
How old do they have to be to be included in TrialNet? We have a one year old.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:20:51 PM EST 2011
Uh, son had a bad experience "donating" a tube of blood for DAISY in Nov.--passed out, fell.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:21:49 PM EST 2011
Sorry, my computer blocked....
i'm back...let me address your questions

Registered User NomadIvy Mom to 4, K dx'd 04/10  (114.185.101.152) Tue Feb 22 09:21:52 PM EST 2011
Does anyone know if TrialNet is being done in Japan? We are in Tokyo most of the year.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:22:24 PM EST 2011
first, family members need to be at least 1 year old.

Registered User NomadIvy Mom to 4, K dx'd 04/10  (114.185.101.152) Tue Feb 22 09:22:44 PM EST 2011
Ooo, Brenda, sorry to hear that.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:23:10 PM EST 2011
second, if someone is found to be antibody positive, TrialNet investigators will talk with the family about all studies they could qualify for

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:23:27 PM EST 2011
TrialNet was discussed in our CWD forums recently and one of the moms said, "After my daughter was diagnosed we had our oldest son tested through Trial Net. His blood work showed no antibodies, but about 4 months later he was diagnosed with type 1. We were shocked. The negative Trial Net results gave us a false sense of security."

Would you care to comment aboutthis situation?

Registered User NomadIvy Mom to 4, K dx'd 04/10  (114.185.101.152) Tue Feb 22 09:24:05 PM EST 2011
Benjamin will be 16 months by the time of the conference. Oh, so it will be useless for us anyway since we will be coming back to Tokyo end of August...

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:24:09 PM EST 2011
Brenda,
I too am sorry that your son had a bad time with his blood draw. It is important to keep in mind that the people drawing blood are experienced and can deal with the problems that can (rarely!) occur.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:24:59 PM EST 2011
Brenda,
it is also important to let people know in the future that your child had trouble with a blood draw. That would be true for any blood draw - part of a study or just clinical care. They should be sure he lies down.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:25:49 PM EST 2011
NomadIvy,
You don't need to wait until the CWD conference. Get your family screened through the regular channels (through TN site or test kit).

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:26:34 PM EST 2011
She's in Tokyo.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:27:33 PM EST 2011
Brenda,
Regarding the question about how someone could get diabetes without having antibodies. I'm sure this must have been a big surprise. However, no test is always 100% perfect. The risk for diabetes in family members is very low if the antibodies are negative. There may be other antibodies that we dont yet know how to measure.

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:28:25 PM EST 2011
I think the important thing to remember with this is that there are very dew certainties in life, and a negative test only means negative at that point in time. However, is it possible to have the antibodies and NOT develop Diabetes?

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:28:40 PM EST 2011
Though I know little about it, do you test for ZN8? I think that's what it's called. I just know that it's relatively new.

Registered User NomadIvy Mom to 4, K dx'd 04/10  (114.185.101.152) Tue Feb 22 09:28:53 PM EST 2011
I wonder if our endo here can work with TrialNet there? He has several patients who are foreigners..mostly from the U.S.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:29:21 PM EST 2011
Oops, sorry I missed the Tokyo reference. While there are TN sites in Australia and Europe as well as North America, there is no site in Toyko. Maybe would be best to have you contact my team here at 800-888-4187 and we can figure out how to help you in particular.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:30:40 PM EST 2011
Up until recently, TN tested only for 4 antibodies (ICA512, mIAA, GAD65, ICA). However, now that we have validate the ZNT8 antibodies, we will be officially using that in the study as well.

Registered User NomadIvy Mom to 4, K dx'd 04/10  (114.185.101.152) Tue Feb 22 09:31:33 PM EST 2011
Okay, referenced. thank you

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:32:35 PM EST 2011
Scott,
If you have only one antibody, the risk for diabetes is low (less than 5% over 5 years). If you have more than one antibody, the risk is at least 25% over 5 years. Depending on how many antibodies and results of other tests, there are some people who will have ~80% risk of diabetes. Individiuals at these higher risks are the ones that may be eligible for prevention studies.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:34:07 PM EST 2011
I should probably emphasize that in addition to TrialNet sites and test kits, there is often an opportunity to get tested at events such as CWD

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:34:16 PM EST 2011
With TrialNet being called a study, does this mean there is a finite time frame, or is the plan to keep collecting data indefinitely?

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:35:04 PM EST 2011
Remember, it is not just the immediate family that should get tested. Please be sure that cousins, neices, nephews, aunts, uncles, and grandchildren get tested as well.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:36:26 PM EST 2011
Scott,
Good question. The big picture is that we anticipate that screening for type 1 diabetes risk will eventually become part of routine clinical care...However, that will require us to have a therapy that delays or prevents diabetes. The more people we identify at risk, and the sooner we do it, the more likely we can find such a therapy.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:37:29 PM EST 2011
I guess what I really was wanting to say, is that we expect to continue this screening process idenfinately...but we really don't want people to wait...the cure for diabetes will require getting clinical trials done!

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:37:51 PM EST 2011
That was actually going to be my next question. Why isn't this screening done automatically after the dx of a family member.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:38:23 PM EST 2011
Scott's son is a triplet (right??). Does that mean his siblings are at an even greater risk for having the antibodies?

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:39:37 PM EST 2011
My son Ryan is an 8 y/o triplet and has a 12 year old brother. When he was originally dx'd we were told that because he wasn't identical, his siblings risks were that of the general population, and not greater because of family ties. I didn't put a lot of faith in that answer though.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:39:51 PM EST 2011
Scott,
We would LOVE to have this done automatically. It would greatly help research. But, it is still research...and thus not part of "standard of care" yet. We work hard to let diabetes health care professionals know to tell their patients about getting family members tested, but unforutnately, the vast majority of people with type 1 diabetes don't know about this testing!

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:40:08 PM EST 2011
Depending on the age of the person at diagnosis, not all family members could be present. For example, for an 18-year-old, his siblings might not even visit if they are older. Depends, I suppose.

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:40:25 PM EST 2011
well we'll just have to work on changing that then. :)

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:40:56 PM EST 2011
Scott,
Happy to see that you are skeptical about the answer you got about his sibling risks. It is true that IDENTICAL twins (or triplets) would have a higher risk than non-identical; but the risk overall of family members is still 15X greater than no family member.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:41:15 PM EST 2011
Well, in our case, Marissa's siblings had not even been born when she was diagnosed.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:42:09 PM EST 2011
Remember, we don't need to test all the family members at the same time. In fact, since people move so much in America - we expect that many families are spread out throughout the country. We just need to be sure that they KNOW about the opportunity to get tested.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:43:13 PM EST 2011
TrialNet appreciates the help in getting the word out among individuals with diabetes whether they were recently diagnosed or have had diabetes for decades.

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:43:34 PM EST 2011
Just figuring this would be a common question. Does any of this need to be cleared through an individual's insurance company?

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:44:12 PM EST 2011
You may be interested to know that TrialNet has screened about 90,000 relatives. We need to more than double that number to identify those for preventioin studies!

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:45:12 PM EST 2011
Trialnet screening is FREE, and no information goes to the insurance company. (we often give kids a token "prize" to thank them for participation)

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:46:43 PM EST 2011
Sometimes families may be wanting to wait until their child is older to be tested. Unfortuatnely, that is not a good idea. The age group with the biggest increase in type 1 diabetes are kids under age 5.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:47:58 PM EST 2011
I often get the question about how families can be at increased risks if noone in the family had diabetes before

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:48:24 PM EST 2011
Dr. Greenbaum, what are some of the things that you have been able to discover as a result of the program?

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:48:32 PM EST 2011
The answer is a bit complicated. If there are 100 people newly diagnosed wiht diabetes who come into my office, about 80-or 90 will have had NO family member with diabetes.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:49:05 PM EST 2011
These 80 or 90 people represent the 3/1000 who get diabetes from the "general population", that is people without diabetes.

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 09:49:50 PM EST 2011
Is the data being shared with other organizations, or just findings?

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:50:08 PM EST 2011
The other 10-20 people come from a family with diabetes. They represent the 5/100 that get diabetes from a family history. The difference between 3/1000 and 5/100 is 15X. That is why we focus on family members

Registered User Brenda mom of Marissa, 22, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:50:14 PM EST 2011
We had NO relatives with diabetes.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:51:35 PM EST 2011
Data from research studies is shared widely with other investigators, but only DATA!, no individual identifying information is EVER shared. Noones name, birthdate, family history, etc is ever shared. There are strict rules and procedures in place to protect privacy and confidentiality. But sharing research data helps everyone

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:52:52 PM EST 2011
Brenda,
Having no relatives with diabetes is the MOST common situation (about 80-90 of every 100 people). But, the rest of the family is at risk.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:53:44 PM EST 2011
You know, when we find a way to stop the immune system from destroying the beta cells, that will really help people who have had diabetes for many years as well.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:54:31 PM EST 2011
That is because, whether we replace lost beta cells with new ones or artificial ones, we will still need to STOP the immune system from destroying the beta cells

Registered User Brenda mom of Marissa, 22, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:55:12 PM EST 2011
We certainly hope you can do that!

Registered User KimbyCox Mom to 5 kids, 1 T1D dxd 1/08  (72.148.24.225) Tue Feb 22 09:55:20 PM EST 2011
Hi! I just wanted to give a quick testimony. My daughter chose to participate at the first opportunity after Andrew's dx. She was positive for 4 antibodies & has impaired glucose. I asked her opinion of Trialnet. She said that she is glad she did it because she's helping find a cure, she learns more every time she goes, she loves the nurses, & they check on her.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:55:21 PM EST 2011
We currently have TWO prevention studies for people found to be at risk for type 1 diabetes.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:56:35 PM EST 2011
Dear KimbyCox,
What a great testimony. I have to say that kids tolerate all of this quite well! All sites work hard to make the whole experience as pleasant as possible.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:58:25 PM EST 2011
KimbyCox,
Your statement also highlights another benefit to participation. This is the chance to spend time learning about cutting edge research and being a part of the effort

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 09:59:31 PM EST 2011
As we come to the end of our hour, does anyone else have a last question or comment for Dr. Greenbaum?

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 09:59:58 PM EST 2011
Note, the prevention studies are also FREE to participants. You get into the studies by being identified through the TrialNet screening.

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 10:00:30 PM EST 2011
I'm fresh out of questions!

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 10:00:34 PM EST 2011
Also - don't forget, about 1/2 of the people who get diabetes are adults - so older sibs and PARENTS should also be screened.

Registered User ScottHerring Ryan's Dad  (24.115.234.243) Tue Feb 22 10:00:54 PM EST 2011
Thank you Dr. Greenbaum.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 10:01:25 PM EST 2011
We really appreciate people being TrialNet ambassadors - getting the word out about risk and screening. Feel free to contact my team here in Seattle at 8008884187 or go to the TrialNet web site for more information.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 10:01:43 PM EST 2011
Many many thanks to CWD for inviting me here tonight!

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Feb 22 10:01:53 PM EST 2011
Thank you Dr. Greenbaum for such an informative chat. We appreciate you taking the time from your evening.

Registered User Dr. Greenbaum Principal InvestigatorI withTrialNet and Director of Diabetes Program at Benaroya Research Institut  (38.102.1.1) Tue Feb 22 10:04:39 PM EST 2011
Goodnight and "signing-off".



                 
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Last Updated: Thursday February 24, 2011 18:05:32
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