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  Back to Chat TrialNet Oral Insulin Trial

Registered User Moderator   (server) Tue Apr 12 08:00:00 PM EDT 2011
Our chat about the TrialNet Oral Insulin Trial with Dr. Bruce Buckingham starts at 9pm Eastern.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:00:16 PM EDT 2011
Good evening. Who else is here?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:00:17 PM EDT 2011
Hello, I am Bruce Buckingham a pediatric endocrinologist at Stanford and I am here with Darrell Wilson, MD, the TrialNet Principal Investigator at Stanford we are here to discuss the Oral Insulin Diabetes Prevention Study being conducted by TrialNet

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:00:57 PM EDT 2011
Hi Brenda

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:02:25 PM EDT 2011
Hi. How should we address you this evening? Bruce? Dr. B?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:03:02 PM EDT 2011
Anything works. Perhaps the shortest

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:03:27 PM EDT 2011
I was not aware that TrialNet was doing a study with oral insulin. Who are the participants?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:04:43 PM EDT 2011
We screen family members who are at risk for developing diabetes, and if they have antibodies against insulin they are elgible

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:05:16 PM EDT 2011
Age range for paticipants is 3 to 45 years old.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:05:46 PM EDT 2011
So, it's not the person with type 1, correct? Is there info on the TrialNet web site?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:06:39 PM EDT 2011
Correct. It is a relative who has not yet developed diabetes. Information is available on the TrialNet website

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:08:52 PM EDT 2011
Do you have to live in a certain geographic area to participate (thinking that certain centers might definintely do this--yours, Joslin, Barbara Davis Center, etc.)?

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:10:32 PM EDT 2011
And, how is the oral insulin administered? Is it a pill, liquid? Just trying to see how a three year old could swallow a pill.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:10:37 PM EDT 2011
There are hundreds of TrialNet sites throughout the United States where screeing is available. You get log in and sign up for more information at the TrialNet website.

Registered User Dr Darrell Wilson Trialnet investigator at Stanford  (171.65.96.46) Tue Apr 12 09:10:57 PM EDT 2011
Hi
Darrell Wilson joins

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:11:08 PM EDT 2011
Screening can also be done by reciving a screening kit through the mail, and can be done at a local laboratory.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:11:32 PM EDT 2011
Hi Darrell, happy to have you here with us tonight

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:12:23 PM EDT 2011
This is a randomized, controlled, double-blinded study. Neither the subject or the treating doctor know if you are receiving insulin or the placebo.
½ the subject will receive insulin. Insulin is given as a capsule before breakfast. For young children the insulin can be sprinkled into applesauce or cereal.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:12:39 PM EDT 2011
Should we consider having Tim and Kathryn participate even though they have already had testing through DAISY that says they do not have the markers for diabetes?

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:13:49 PM EDT 2011
How many more patients are you hoping to enroll and how long will the study go on?

Registered User Dr Darrell Wilson Trialnet investigator at Stanford  (171.65.96.46) Tue Apr 12 09:14:02 PM EDT 2011
By the way, the public TrialNet website address is
http://www.diabetestrialnet.org/
which has more details about screening

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:14:22 PM EDT 2011
If they were tested over a year ago, it may be worthwile testing them again for the antibodies. Of course if they had genetic markers giving them a minimal risk of diabetes, they may not need testing.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:14:26 PM EDT 2011
Currently 228 have enrolled in the study. Our goal is 330 participants.
We have screened 88,769 family members to enroll the 228 subjects.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:15:00 PM EDT 2011
Kids were just tested in November.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:15:45 PM EDT 2011
The very important message we want to give families is that in past studies with oral insulin, the higher the antibodies, the greater the benefit from receiving oral insulin.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:15:54 PM EDT 2011
Part of the issue is that many people just don't want to know if they have aa child at risk (speaking about those who already have a child with type 1).

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:16:02 PM EDT 2011
The group with insulin antibodies greater than 80 nU/ml had a 5 year delay in the onset of diabetes (130 subjects)
The group with insulin antibodies greater than 300 nU/ml had a 5 year delay in the onset of diabetes (69 subjects)

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:16:48 PM EDT 2011
What is the benefit of oral insulin if you have antibodies, but not actually type 1? Is there any risk?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:17:27 PM EDT 2011
If there was a possibility of delaying the onset of diabetes by 5-10 years, wouldn't that make you want to know the results of the testing, since there is something to offer your child?

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:17:34 PM EDT 2011
So, Dr. B, both groups had a 5 year delay?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:18:12 PM EDT 2011
In our initial stuyd of 186 subjects treated over 5 years, there were no side effects.

Registered User Dr Darrell Wilson Trialnet investigator at Stanford  (171.65.96.46) Tue Apr 12 09:18:18 PM EDT 2011
Hi Brenda
I find that many families change their minds when they they learn there is something to actually do (the study) if they have antibodies

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:18:40 PM EDT 2011
The group with higher antibodies had the longer delay.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:19:06 PM EDT 2011
Not sure. I think the issue is that people are scared to find out. But, I think it would be beneficial to know, to be able to participate in a study to delay the onset.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:21:40 PM EDT 2011
This is a study without a huge burden tot he subject. The visits are every 6 months, and the medication is given orally each morning. Participation in the study is without cost to the subject.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:21:46 PM EDT 2011
Do the antibodies' results ever fluctuate? Seems like I've seen some people test negative, then positive. Can it be the opposite--positive, then negative?

Registered User Dr Darrell Wilson Trialnet investigator at Stanford  (171.65.96.46) Tue Apr 12 09:21:59 PM EDT 2011
For more details, and to review a consent form for both the natural history (which is the pathway to the oral insulin study) or the oral insulin study itself
You can look at Stanford's site
dped.stanford.edu
and go to the research tab

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:23:11 PM EDT 2011
Thanks, Dr. W. I am hoping that everyone else is just busy tonight and will read the chat to find out what we've discussed. Smile 

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:23:46 PM EDT 2011
Yes, low titers of antibodies can fluctuate. You only need one insulin autoantibody test to be positive to join the study, but you also need to have a second antibody (like islet cell antibody, GAD-65 antibody, ICA-512 antiody) to also be positive.

Registered User Dr Darrell Wilson Trialnet investigator at Stanford  (171.65.96.46) Tue Apr 12 09:26:12 PM EDT 2011
Another reason for relatives to be screened in the TrialNet Natural History study is that it is the pathway to join other prevention study. So if you have antibodies other than the insulin autoantibody, other studies will likely be starting.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:26:26 PM EDT 2011
Say hello to Marrissa

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:27:00 PM EDT 2011
So, back to a previous question. If we, for example, were to participate, would we just need lab work every six months? That would be shipped to you?

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:27:56 PM EDT 2011
And, either I missed this or forgot to ask: How long does the study go on? Is there a timeframe?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:28:45 PM EDT 2011
If you were in the study, you would come to a TrialNet center or Affiliate every 6 months for an oral glucose tolerance test (it takes about 2 hours).

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:28:50 PM EDT 2011
Will send greetings to Marissa. She's been enjoying the Cardio floor for her latest rotation--six weeks or so in various locations.

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:29:26 PM EDT 2011
Hi Brenda - just saw your post on FB

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:29:39 PM EDT 2011
We would like to follow participants for several years, we anticipate recruitment ending in about 2015.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:30:06 PM EDT 2011
When she was here a few weeks ago, Marissa spent almost 3 hours participating in some follow-up to a study. Don't recall which one. She said she won't do it again because she had to fast!

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:30:38 PM EDT 2011
Chris, do you have any other children? Have you had them tested through TrialNet?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:31:01 PM EDT 2011
In this study you get oral glucose as a breakfast orange drink

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:31:02 PM EDT 2011
At the risk of repeating a question - if Elizabeth tested positive for an antibody is she eligible and what is the benefit?

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:31:43 PM EDT 2011
Mmmm, yum at the oral glucose. LOL 

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:32:03 PM EDT 2011
She would be elgible, and the benefit is a possible 5-10 year delay in the onset of diabetes (we saw this in a previous study)

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:32:31 PM EDT 2011
Everyone's been tested (we have 4). Only Elizabeth has had a positive GAD a few years back. Ben and Andrew in the clear so far.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:33:58 PM EDT 2011
There may be a study in the next year or so using a GAD vaccine for those who are GAD positive. TrialNet may contact you in the future

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:33:59 PM EDT 2011
Oh, I was wondering why you were only talking about Elizabeth. They HAVE had some testing. Was Elizabeth tested for other antibodies?

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:34:19 PM EDT 2011
I think I may have talked to someone previously (Laurie Feldman?) about this but it hadn't started yet

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:34:30 PM EDT 2011
The results of using GAD vaccine at the onset of diabetes will be available in June at the ADA meeting.

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:35:36 PM EDT 2011
She went through the whole TrialNet testing a few times...problem is her history of the bone marrow transplant - not sure if that excludes her from some trials...

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:36:28 PM EDT 2011
Chris, I don't think I knew about that. Eek  Is she okay?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:36:39 PM EDT 2011
Would depend on the trial. If you is on immunosuppressive drugs, that would be an exclusion for most studies

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:38:36 PM EDT 2011
Yes - she's great. Had a nasty genetic immune system disease called HLH when she was a baby. Zapped hers, gave her someone else's and she's good as new. Was a little tricky there for a while though. But no immunosuppressants. She is on methimazole for hyperthyroid though.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:38:39 PM EDT 2011
Was the GAD vaccine study through TrialNet?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:39:33 PM EDT 2011
Yes, there was one through TrialNet and one from the company (Diamyd)both in new onsets.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:39:40 PM EDT 2011
Chris, you coming to FFL? Dr. B. is coming back this year!

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:40:22 PM EDT 2011
Yes I am excited to be back again with all the families. A great event.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:41:35 PM EDT 2011
There always seem to be lots of trials for new onset cases. Anyone trying similary trials for the "old timers?" Could any of TrialNet's studies be used by long term type 1? Or, do they need to have some of their own islet cells?

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:41:41 PM EDT 2011
So if I want to get more info on this and maybe getting her involved if she's eligible, what do I do next? And yes Brenda, we'll be there - wouldn't miss it for the world. I actually offered to volunteer with the trialnet people doing blood draws if they needed - figured it's what I do for a living anyway:)!

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:41:52 PM EDT 2011
Jen and Darrell also say hello to Marrisa.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:43:48 PM EDT 2011
there is increasing data that many old times may still have the ability to have a small amount of islet cell function, and this raises the possiblity of islet regeneration.

Registered User Dr Darrell Wilson Trialnet investigator at Stanford  (171.65.96.46) Tue Apr 12 09:44:22 PM EDT 2011
There is one study that going out to two years after onset

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:44:37 PM EDT 2011
A study in pregnancy showed that old timers at the onset of their pregnancy could not make insulin, but by the end of the pregnancy they could.

Registered User Dr Darrell Wilson Trialnet investigator at Stanford  (171.65.96.46) Tue Apr 12 09:45:26 PM EDT 2011
Here is the listing for that trial
ATG/GCSF Clinical Trial (Diagnosis > than 4 months but < than 2 years)
http://diabetes.ufl.edu/research/clinical-trials-and-studies/established-type-1-diabetes/atggcsf-clinical-trial/
UF Contact: madennis@ufl.edu

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:45:33 PM EDT 2011
I think I once heard David Harlan talking about the old timers still having/producing C-Peptide. I don't know the proper termininology.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:46:13 PM EDT 2011
Therapies developed at the onset of diabetes could be use to help in creating an environment which could allow some islet regeneration (or islet protection from immune attach) in the well established person with diabetes.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:47:10 PM EDT 2011
David did a study using exenatide to try and improve islet regeneration. The study did not show a significant effect, but it may take a combination of agents.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:48:01 PM EDT 2011
To get back to the Oral Insulin Trial, the best way to treat diabetes is to prevent it from developing.

Registered User Dr Darrell Wilson Trialnet investigator at Stanford  (171.65.96.46) Tue Apr 12 09:48:22 PM EDT 2011
One additional trial that extends up to two years after diagnosis is

T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs (Newly Diagnosed)
http://www.clinicaltrials.gov/ct2/show/NCT01210664?term=Tregs&cond=Diabetes&rank=1
UCSF Contact: Kfraser@diabetes.ucsf.edu

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:49:08 PM EDT 2011
Who do I contact to see if Elizabeth is eligible?

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:49:09 PM EDT 2011
Oral insulin treatment can potentially delay the onset of diabetes by 5-10 years, if that bought time to get someone through adolescence, that is a huge benefit.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:49:21 PM EDT 2011
Interesting about pregnant women--what happens when they give birth? Do they revert to their pre-pregnancy state or have a "second honeymoon?" Even more interesting because many women actually develop gestational d.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:50:32 PM EDT 2011
Brenda, while they are breast feeding they continue to make their own insulin, and once they stop breast feeding it is hard to detect residual insulin secretion.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:51:31 PM EDT 2011
Chris, which study are you referring to? If it is a TrialNet study, go to the Trialnet website which Darrell provided earlier

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:51:33 PM EDT 2011
That is very interesting, Bruce.

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:52:42 PM EDT 2011
Sorry, I came in late so I missed it. I can look back through the transcript when it's posted. I was referring to the one for kids who tested antibody positive.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:53:26 PM EDT 2011
I think you can find the info on the TrialNet web site, Chris.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:54:14 PM EDT 2011
Chris, That would be the TrialNet website. If the testing was done through TrialNet, contact the TrialNet site where you he had the testing.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:54:17 PM EDT 2011
http://www.diabetestrialnet.org/studies/oral-insulin.htm

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:55:09 PM EDT 2011
Thanks:)!

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:55:13 PM EDT 2011
Thank you Brenda

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:56:06 PM EDT 2011
It looks like the U of MD Hospital is where you can go unless you are closer to DC. I can't remember where you live.

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:58:02 PM EDT 2011
We're in Baltimore. She's had testing done at the hospital where I work (GBMC), although they then referred he to Uof MD. All of her other testing has been done in the summer at FFL. Her titers haven't changed in number from year to year so we've just kind of sat back and kept an eye out.

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 09:58:49 PM EDT 2011
Looks like our time is just about up. I'd like to thank you, Bruce and Darrell for taking time to answer questions.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:58:51 PM EDT 2011
To summarize, TrialNet is recruiting an additional 100 subjects for a trial to see if oral insulin can delay or prevent the onset of diabetes. A previous study showed that those with the higher anti-insulin antibodies had a 5-10 year delay in the onset of diabetes. The initial step is the have a free screening test through TrialNet.

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 09:59:34 PM EDT 2011
Thanks for the info!

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 09:59:37 PM EDT 2011
Thank you, have a good night

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 10:00:14 PM EDT 2011
And Brenda - off subject - but congrats on Marissa's engagement!!!!

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 10:00:35 PM EDT 2011
Chris, sounds like you need to contact the TrialNet people and ask what your next step is. Maybe there is nothing to do at this point. I don't know; not an expert.
See you at FFL.

Registered User Bruce Buckingham Pediatric Endocrinologist - Stanford  (171.65.97.162) Tue Apr 12 10:00:54 PM EDT 2011
Big News. Congratulations!!

Registered User Brenda mom of Marissa, 23, dx'd 9/89  (216.68.227.240) Tue Apr 12 10:01:05 PM EDT 2011
Thanks Chris. She was not online tonight, but says hello to all.

Registered User Chris Molly's mom, 12, dx'd 3/20/05, omnipod  (69.251.168.14) Tue Apr 12 10:01:47 PM EDT 2011
I'm going to look into that tonight and see if I can make a phone call tomorrow. Thanks for the FB post! See you this summer:)

Registered User Moderator   (server) Tue Apr 12 11:25:00 PM EDT 2011
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