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  Back to Chat Research Update Chat with Dr. Alberto Pugliese

Alberto Pugliese, M.D., head of the Immunogenetics Program at the Diabetes Research Institute, joined us for a special research update chat on July 29, 2003.

Moderator (server) Tue Jul 29 08:00:00 PM EDT 2003
Our DRI Research Update chat starts at 9pm Eastern.


GeekGuyAndy   (24.50.149.22) Tue Jul 29 08:07:36 PM EDT 2003
Ok

Alberto Pugliese   (66.176.129.77) Tue Jul 29 08:57:37 PM EDT 2003
Hi

this is Alberto Pugliese, hope to figure how this works

Jeff Hitchcock   (216.68.227.14) Tue Jul 29 08:58:24 PM EDT 2003
Dr. Pugliese, welcome and thank you for taking the time to chat tonight.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 08:58:54 PM EDT 2003
Hi Jeff
my pleasure to be here

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 08:59:47 PM EDT 2003
Thank you very much for taking the time to be here, Dr. Pugliese. This is a chat I've been looking forward to.

GeekGuyAndy   (24.50.149.22) Tue Jul 29 08:59:58 PM EDT 2003
Hello Jeff, Alberto, Allison..

Jeff Hitchcock   (216.68.227.14) Tue Jul 29 09:00:23 PM EDT 2003
I have a question about testing siblings -- since I am asked a lot about it. What prevention studies are available for families now for kids who don't have diabetes? (given the failure of the DPT-1)

Brenda H.   (216.68.227.14) Tue Jul 29 09:00:25 PM EDT 2003
Dr., although we are not in a position to do this, do you think the banking of newborn cord blood is a good idea?

Sue Type 1  (216.221.81.98) Tue Jul 29 09:00:33 PM EDT 2003
Hi Andy

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:00:34 PM EDT 2003
Hello

Michelle   (64.12.96.46) Tue Jul 29 09:01:25 PM EDT 2003
hi everyone

Sue Type 1  (216.221.81.98) Tue Jul 29 09:01:26 PM EDT 2003
Hi Pet

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:01:30 PM EDT 2003
Allison, hope I can help you with some questions.
Brenda, I don't think banking cord blood is a good idea at this stage

GeekGuyAndy   (24.50.149.22) Tue Jul 29 09:01:32 PM EDT 2003
Hi Sue! and anyone else joining

Laura B Sam's mom (dx'd 8/98, 13)  (68.41.54.181) Tue Jul 29 09:01:51 PM EDT 2003
Good evening, Dr. Pugliese - and everyone. Smile 

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:02:28 PM EDT 2003
Good evening to anyone else joining

Sue Type 1  (216.221.81.98) Tue Jul 29 09:02:37 PM EDT 2003
sent you an email Andy

GeekGuyAndy   (24.50.149.22) Tue Jul 29 09:02:46 PM EDT 2003
Ty Sue

Brenda H.   (216.68.227.14) Tue Jul 29 09:03:02 PM EDT 2003
I had heard that the cord blood might be useful. Why is it not a good idea? Some parents are counting on that cord blood to help cure their children.

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 09:03:22 PM EDT 2003
That's interesting that you say that about cord blood, because I just had a baby 5 months ago and StemCyte was very interested in collecting my cord blood. Probably for more reasons than the diabetes though.

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:04:06 PM EDT 2003
Dr. Pugliese...thank you for joining in. Do you recommend that siblings of type 1 diabetes be tested for antibodies?

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:04:44 PM EDT 2003
Hi Sue and Andy

Sue Type 1  (216.221.81.98) Tue Jul 29 09:05:02 PM EDT 2003
Hey Pet

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:05:25 PM EDT 2003
One can have cord blood banked for a variety of reasons, but at the moment there is very little certainty that frozen cord blood can be helpful to cure diseases or diabetes - a lot of companies are sort of speculating on common perceptions that stem cells or DNA can hold the key to many cures

Jay   (151.199.242.122) Tue Jul 29 09:05:27 PM EDT 2003
Hi Everyone

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:06:35 PM EDT 2003
In response to Pet
siblings of a person with type 1 diabetes should be tested for antibodies with the intention of enrolling in a prevention study

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 09:07:39 PM EDT 2003
For example, Pet, the TRIGR Study that Devyn is participating in is the only reason she was tested.

Lori (KS) Erika, 13, dx'd @ 12, pumping  (24.225.8.162) Tue Jul 29 09:07:41 PM EDT 2003
Hello

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:08:10 PM EDT 2003
the other potential benefit is that if one is found positive, follow up can help make an earlier diagnosis and reduce the risk of acute complications of diabetes, such as ketoacidosis

Lori (KS) Erika, 13, dx'd @ 12, pumping  (24.225.8.162) Tue Jul 29 09:08:16 PM EDT 2003
How and where do you get enrolled in a prevention study?

Brenda H.   (216.68.227.14) Tue Jul 29 09:08:52 PM EDT 2003
We had our other two kids tested and they were neg. I have heard that some parents feel REALLY stressed when their children test positive because they don't know what their next step should be.

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:09:00 PM EDT 2003
Hi Allison..did she test positive?

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 09:09:34 PM EDT 2003
Definitely, Brenda, my 5 month old daughter has tested positive and when I first found out, it drove me crazy. I wanted to test her constantly.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:10:13 PM EDT 2003
one can be relieved if the antibody tests come back negative, but if they are positive that may generate some anxiety - in the end it's a personal choice, but as it often reflects on children parents should be aware of the possible implications

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 09:11:45 PM EDT 2003
So now that I know I have another child who potentially may become d, how's the cure research going?

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:11:53 PM EDT 2003
Lori
as you may know the DPT-1 study has recently been completed. New prevention studies are being planned, a number of trials will begin over the next several months under the umbrella of the TrialNet Study group

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:13:22 PM EDT 2003
Allison
first, you may want to have the test confirmed on a second sample (if you have not done that already);

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 09:14:06 PM EDT 2003
They did a second test already, but I was too afraid to find out the results. I already suffered enough anxiety with the first test, I figured I didn't want to know any more results.

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:14:33 PM EDT 2003
Dr. Pugliese...I've read numerous theories about what actually triggers type 1 diabetes and it seems like there must be several factors that play a role....what is your opinion on the triggers?

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:14:43 PM EDT 2003
There are many research efforts focusing on cure. transplantation of islets and generation of islets from stem cells are just some of those.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:15:42 PM EDT 2003
Allsion
what about if the second test is negative? If it is positive again it does not change your status, if negative you should feel relieved

Sue Steve,11,dx'd at 8..pumping  (131.109.68.49) Tue Jul 29 09:15:45 PM EDT 2003
Hi all..Dr. Is there a way for my son to know if he will pass D on to his children?

patti Mom of Patrick, 17, dx at 16  (24.159.79.116) Tue Jul 29 09:16:27 PM EDT 2003
Good evening all - Does age of child at diagnosis seem to make any difference in sibling developing Type 1?

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 09:16:37 PM EDT 2003
That's a good point, Dr. Pugliese. I will consider it and can check with them at her next appt.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:20:45 PM EDT 2003
Patti
as a rule of thumb, diabetes is most commong in children. The older the person the lower the risk of type 1 diabetes. In identical twins, the risk of developing diabetes in the second twin is very much affected by the age of onset in the first twin. If below 25, the risk is about 35% vs only 6% if diabetes occurred after age 25.

Stacey N. Jesse's mom...  (64.12.96.46) Tue Jul 29 09:21:10 PM EDT 2003
good evening

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:23:41 PM EDT 2003
Triggers of diabetes: viruses appear to be the main suspects, but it may not be only one. It may be that one needs repeated viral infections to promote autoimmunity. Curiously though, mice that spontaneously develop diabetes do so at higher frequency when housed in germ free conditions. In Finland, a country with possibly the highest incidence of type 1 diabetes, enterovirus infections are associated with disease, but the frequency of these infections in the populations is decreasing while the incidence of diabetes is increasing.

patti Mom of Patrick, 17, dx at 16  (24.159.79.116) Tue Jul 29 09:25:10 PM EDT 2003
Thank you - we did not test his older brother thinking we would recognize the symptoms more quickly this time. I did not feel he would want to participate in prevention studies as he is in college and studying overseas. And your point of worrying a great deal about positive results is so true.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:25:36 PM EDT 2003
Sue
we can't tell for sure whether your son will pass diabetes to his offspring, but some genetic tests can help estimate risk

Jay   (151.199.242.122) Tue Jul 29 09:25:39 PM EDT 2003
You say that viruses are one trigger. I was diagnosed with Spinal Menengitis after a Measels Mumps and Measels shot at 1. At 2 I was diagnosed with Diabetes.

MARSH FATHER OF 11 YEAR OLD BOY, NEWLY DIAGNOSED  (205.188.208.6) Tue Jul 29 09:26:46 PM EDT 2003
How is everyone? Have you heard of Ala-Ala?

Sue Steve,11,dx'd at 8..pumping  (131.109.68.49) Tue Jul 29 09:27:06 PM EDT 2003
Thank you

Brenda H.   (216.68.227.14) Tue Jul 29 09:27:18 PM EDT 2003
Some people also claim that vaccines cause diabetes, but that doesn't always make sense to me, esp. for teens who are not routinely getting vaccinated.

Lori (KS) Erika, 13, dx'd @ 12, pumping  (24.225.8.162) Tue Jul 29 09:27:19 PM EDT 2003
It seems like Erika was hardly ever sick when she was younger. As a matter of fact, she is hardly ever sick now (knock on wood). Maybe just more of a case where it is on both sides of the family.

Ann Philip,14  (216.40.163.234) Tue Jul 29 09:27:25 PM EDT 2003
This is transcipt from the May update. Are there any findings on cloning islets? and what is the update on immunosuppression drugs?
Camillo Ricordi (129.171.137.81) Tue May 20 09:29:25 PM EDT 2003
Jeff, the success rate is currently approximately 80% at one year post islet transplant and 70% at 2 years, but I do not believe that the current immunosuppression (i.e., Edmonton protocol) will be used for much longer, because there is still significant toxicity from this immunosuppression and this will limit the application to the most severe cases. I am confident that we will see much improved protocols (and less toxic) in the next year or so. Then we can discuss younger recipients.

Mel Mum of Eilish, 6 dxd at 3  (219.88.1.65) Tue Jul 29 09:28:05 PM EDT 2003
Good evening all, sorry I'm late tuning in. Dr. Pugliese, can you tell me how reliable and efficient is the glucowatch in your opinion?

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:28:10 PM EDT 2003
Ala-Ala

you mean the antibody against CD3 used in patients with new onset diabetes (Herold trial at Columbia)?

GeekGuyAndy   (24.50.149.22) Tue Jul 29 09:28:18 PM EDT 2003
Lori, I was the same way. Rarely missed school for being sick. Maybe 1 day a year.

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:28:46 PM EDT 2003
Dr. Pugliese...I've heard some talk of the Cocksackie virus. My daughter was on an antibiotic for over 6 months due to frequent ear infections...good that cause the "germ free" environment you mentioned earlier?

Anne Mastrototaro Mom of two children with IDDM, Massachusetts  (151.203.146.167) Tue Jul 29 09:29:19 PM EDT 2003
Good evening all, sorry i am late. I am wondering Dr. what the general recommendations are for testing older siblings? My oldest is 20, tested negative for ICA several yrs. ago. We have not repeated the testing. His 2 younger sibs have diabetes, dx. at ages 2 and 6.

MARSH FATHER OF 11 YEAR OLD BOY, NEWLY DIAGNOSED  (205.188.208.6) Tue Jul 29 09:29:46 PM EDT 2003
yes, that's the one. what is the benefit? I would love to keep his honeymoon indefinately

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:30:27 PM EDT 2003
I haven't followed the glucowatch story closely as I focus on research, but I spoke with a colleague who has tested it in a clinical study at the ADA meeting and he told me that it needs some more improvements

Stacey N. Jesse's mom...  (64.12.96.46) Tue Jul 29 09:30:30 PM EDT 2003
Jesse was dx'd about 6 weeks after having coxsackie.... It was the 3rd time in two years that he had it.

MARSH FATHER OF 11 YEAR OLD BOY, NEWLY DIAGNOSED  (205.188.208.6) Tue Jul 29 09:32:04 PM EDT 2003
What is Heroald's reputation for success?

Brenda H.   (216.68.227.14) Tue Jul 29 09:32:17 PM EDT 2003
Ann, at the recent CWD Conference in Orlando, a Dr. Edelman reported that the success rate of the islet transplants was much smaller, either 8 or 12%. He did not indicate this procedure was not going to work, though. Just an issue of having enough islets and perfecting the procedure.

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:32:20 PM EDT 2003
Stacey N. what are the symptoms of Cocksackie?

Brenda H.   (216.68.227.14) Tue Jul 29 09:33:49 PM EDT 2003
Marsh, for info on Dr. Herold's study, see /d_0j_124.htm

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:34:01 PM EDT 2003
Anne
see my earlier responses about testing and age of onset in siblings

patti Mom of Patrick, 17, dx at 16  (24.159.79.116) Tue Jul 29 09:34:19 PM EDT 2003
Dr. Pugliese - Is there any chance of convincing peripheral stem cells to become islet cells?

Brenda H.   (216.68.227.14) Tue Jul 29 09:35:29 PM EDT 2003
That study is the Ala-Ala, "monoclonal antibody called hOKT3gamma1(Ala-Ala)," used to stop the progression of Type 1.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:35:53 PM EDT 2003
patti
if you talk to stem cells real loud chances are they will listen and become islet cells... just kidding.. I think it is possible, but it is not as simple as some recent reports may lead to believe

Stacey N. Jesse's mom...  (64.12.96.46) Tue Jul 29 09:36:52 PM EDT 2003
Pet-
he had a fever of 102 for a few days , then little blisters in his mouth... wouldnt eat anything except ices...

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:37:38 PM EDT 2003
The CD3 trial showed preservation of insulin secretion in the treated patients - however, none of them went off insulin

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:39:15 PM EDT 2003
Dr. Pugliese...in your opinion, could the prolonged use of antibiotics cause a "germ free" environment and perhaps cause autoimmunity... at age 3-4, my daughter was on an antibiotic for over 6 months due to recurring ear infections.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:40:22 PM EDT 2003
Patti
going back to stem cells, the formation of islets is a very complex process that takes place during the fetal development. Remember that islets form in the context of the pancreas. Helena Edlund at our Institute as well as many other scientists have shown that this process is highly regulated. However, there has been a lot of progress in identifying factors that control this process. The hope is that we can replicate it when we know how it works.

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:41:36 PM EDT 2003
One more question and I'll be quiet...is there ANY convincing evidence that cow's milk plays a factor in onset of type 1?

Brenda H. mom of Marissa, 15, dx'd 9/89  (216.68.227.14) Tue Jul 29 09:42:33 PM EDT 2003
Assuming that you can "teach" stem cells to become islet cells, would you need a large number of stem cells to produce enough islets?

sue type 1  (216.221.81.98) Tue Jul 29 09:42:59 PM EDT 2003
thank you Pet! I was wondering the same thing

patti Mom of Patrick, 17, dx at 16  (24.159.79.116) Tue Jul 29 09:43:16 PM EDT 2003
In the event you could yell loud enough :>) why would the autoantibody not destroy the new islet cells like it had the old? I assume the genetic markers would be the same.
Thanks

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:43:53 PM EDT 2003
Pet
No, if one has an infection that must be treated. If an infection triggers diabetes it will do so even if antibiotics are given. Antibiotics cannot really create a germ free environment. I mentioned this finding in mice because I wanted to highlight the concept that improved sanitation may lessen the chances of certain infections that can actually contribute to a normal behavior of the immune system. As for cow's milk, the TRIGR study will either prove or disprove a role for cow's milk in diabetes. I think most of the evidence comes from Finland, the evidence is a bit weaker in other populations.

TJ I am 16 from NY and I play lacrosse  (24.187.33.163) Tue Jul 29 09:44:21 PM EDT 2003
Hi Mrs.H tell Marissa that I sent the pictures in the mail

Brenda H. mom of Marissa, 15, dx'd 9/89  (216.68.227.14) Tue Jul 29 09:45:15 PM EDT 2003
OK, TJ, I will tell her.

TJ I am 16 from NY and I play lacrosse  (24.187.33.163) Tue Jul 29 09:45:25 PM EDT 2003
thank you

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:46:15 PM EDT 2003
Patti
this is a very real possibility. the immune system has memory cells that can react against insulin producing cells. This is why one needs to devise strategies to re-educate the immune system to accept islet cells. So we'll have to yell to stem cells and immune cells

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:48:48 PM EDT 2003
In fact my own research is focused on understanding how the immune system loses tolerance to islets and starts the autoimmune attack. To an extent, this is genetically determined. Loss of tolerance is a critical step in the disease process, and the ability to restore tolerance is critical for any cure to really work

Ellen (FL) Zack 15  (205.188.208.6) Tue Jul 29 09:48:59 PM EDT 2003
How are the studies with encapsulation coming along Dr. Pugliese? Do you think our loved ones will be able to receive encapsulated islets that are protected from the normal chains of attack?

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:49:39 PM EDT 2003
hope I am keeping up good, if I have missed somebody's question please post again

patti Mom of Patrick, 17, dx at 16  (24.159.79.116) Tue Jul 29 09:50:36 PM EDT 2003
Dr. Pugliese - Could you tell us more about the strategies that show the most promise. And is there a new generation of immunosuppresive drugs that would make the transplant and treatment less dangerous?
Thanks

Brenda H. mom of Marissa, 15, dx'd 9/89  (216.68.227.14) Tue Jul 29 09:51:15 PM EDT 2003
So, Dr. Pugliese, you are saying that you are trying to determine if it's cow's milk, a cocksackie virus, or the phase of the moon that causes one's body to attack itself?

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:51:17 PM EDT 2003
Hi Ellen
hope you and Zack are doing fine. haven't seen you in a while. I have not heard of major breakthroughs in the field of encapsulation - remember, capsules cannot stop certain small substances that can damage islets

Ellen (FL) Zack 15  (205.188.208.6) Tue Jul 29 09:52:26 PM EDT 2003
We're doing well thank you. Still one of your greatest fans  Grin 

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:54:18 PM EDT 2003
Patti
immunosuppressive regimens are under continuous evolution and are likely to become more effective. However, in the long run you would want treatments that specifically prevent the immune system from doing bad things without having generalized immunosuppression and side effects. Antigen-based therapies may prove effective if we can figure out the best way to give them, and may be much safer

Ellen (FL) Zack 15  (205.188.208.6) Tue Jul 29 09:56:20 PM EDT 2003
For anyone interested:

http://www.jci.org/cgi/content/full/111/9/1280

Peptide-based treatment for autoimmune diseases: learning how to handle a double-edged sword
Alberto Pugliese
Departments of Medicine, and Immunology and Microbiology, Immunogenetics Program, Diabetes Research Institute, University of Miami, Miami, Florida, USA

Jeff Hitchcock   (216.68.227.14) Tue Jul 29 09:56:23 PM EDT 2003
Dr. Pugliese, it's approaching 10pm and I'd like to thank you again for taking time to enlighten us all about the current research progress.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:57:53 PM EDT 2003
Brenda
my own research is focused on how certain genes make it possible for the immune system to attack the islets. It deals with critical events occuring early in life that shape the reactivity of the immune system. We are working with cells that are regulator of the immune response, and we hope that one day these cells can specifically regulate immunity and restore tolerance for the specific islet molecules that are attacked in diabetes. I hope that the phase of the moon has nothing to do with it otherwise we'll never figure it out!

Alberto Pugliese   (66.176.129.77) Tue Jul 29 09:58:24 PM EDT 2003
Ellen
you really are a fan! thanks

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 09:59:35 PM EDT 2003
Thank you, Dr. Pugliese

patti Mom of Patrick, 17, dx at 16  (24.159.79.116) Tue Jul 29 09:59:59 PM EDT 2003
Thanks Dr. Pugliese

Jeff Hitchcock   (216.68.227.14) Tue Jul 29 10:00:04 PM EDT 2003
Dr. Pugliese, we're all fans of the DRI. I for one am very hopeful about the prospects for a cure, knowing that the team at the DRI is working on it.

Ellen (FL) Zack 15  (205.188.208.6) Tue Jul 29 10:00:12 PM EDT 2003
Dr. Pugliese, as parents of children with diabetes, we so appreciate your dedication to work to cure diabetes. You'll never know how much!!

GeekGuyAndy   (24.50.149.22) Tue Jul 29 10:00:18 PM EDT 2003
Is there any reason why some people are autoimmune later than others? I'm 17, just diagnosed, and it seems like it's mostly younger kids being diagnosed.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 10:00:21 PM EDT 2003
Jeff and all others:
thanks for having me, it has been a pleasure to chat with you.

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 10:00:45 PM EDT 2003
Thank you, Dr. Pugliese.

Brenda H. mom of Marissa, 15, dx'd 9/89  (216.68.227.14) Tue Jul 29 10:00:48 PM EDT 2003
So, sounds like you are helping to find out why younger kids get diabetes. Is there maybe some other reason older kids get it? Or, is it just that they have the same "critical events" and they just take longer to get the disease? Just trying to understand. :-)

Allison Sevaun, 5 dx'd @ 3; daughter to Jean, dx'd 1949  (207.213.88.135) Tue Jul 29 10:01:12 PM EDT 2003
Andy, there's a 24 yo young man at my office who was just dx'd 3 months ago.

Alberto Pugliese   (66.176.129.77) Tue Jul 29 10:01:52 PM EDT 2003
Autoimmunity can occur at any age. Some people get autoimmune diabetes much later than you did. Genes playa big role in this, but 17 is a commong age for type 1 diabetes

Stacey N Jesse's mom  (64.12.96.46) Tue Jul 29 10:02:02 PM EDT 2003
my daughter has 2 friends , both male, who were dx'd at 18 years old...

Jeff Hitchcock   (216.68.227.14) Tue Jul 29 10:02:55 PM EDT 2003
While it's time for me to sign off, this room will remain open until 11:30 pm Eastern.

Again, many thanks to Dr. Pugliese for tonight's chat.

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:03:15 PM EDT 2003
I was dx'd at 21

Alberto Pugliese   (66.176.129.77) Tue Jul 29 10:04:11 PM EDT 2003
Thanks again everybody, Good night

Linda Mom of Andrew, 11, dxd at 8, pumping  (24.76.53.46) Tue Jul 29 10:04:41 PM EDT 2003
Thank you for all your hard work and dedication Dr. Pugliese

Mel Mum of Eilish, 6 dxd at 3  (219.88.1.65) Tue Jul 29 10:04:46 PM EDT 2003
Thank you Dr. Pugliese.

sue type 1  (216.221.81.98) Tue Jul 29 10:04:50 PM EDT 2003
Thank You Dr

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 10:05:26 PM EDT 2003
Does anyone know how long it takes from the "critical event", or trigger, until the symptoms show up?

sue type 1  (216.221.81.98) Tue Jul 29 10:08:14 PM EDT 2003
Mark, you still there?

hollie   (150.201.25.190) Tue Jul 29 10:08:48 PM EDT 2003
Does anyone have any idea when there will be a cure for Diabetes?

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:09:32 PM EDT 2003
I am still here

Sue type 1  (216.221.81.98) Tue Jul 29 10:09:33 PM EDT 2003
good question  Confused 

Sue type 1  (216.221.81.98) Tue Jul 29 10:10:17 PM EDT 2003
Mark Hi nice to meet a fellow Type 1  Grin 

hollie   (150.201.25.190) Tue Jul 29 10:10:30 PM EDT 2003
Someone told me the other day that her doctor told her approx. 3-4 years. That is why I was asking!

Pet (MN) Mom of Julia, almost 6, dx'd at 5  (66.188.195.146) Tue Jul 29 10:11:11 PM EDT 2003
I'm going over the the parents room...anyone coming?

Sue type 1  (216.221.81.98) Tue Jul 29 10:11:36 PM EDT 2003
Mark are you on needles or a pump?

hollie   (150.201.25.190) Tue Jul 29 10:11:42 PM EDT 2003
then again someone else told me that htey would never find a cure becasue they make too much money off of the disease.

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:12:19 PM EDT 2003
yes it is nice to meet a fellow type 1

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:12:29 PM EDT 2003
I am using needles

Sue type 1  (216.221.81.98) Tue Jul 29 10:12:35 PM EDT 2003
I've been told that to Hollie  Mad 

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:12:59 PM EDT 2003
Hollie, I was told of a research scientist in our country being very hopeful for a cure in 10 years. We can only hope!

hollie   (150.201.25.190) Tue Jul 29 10:13:03 PM EDT 2003
sad huh?

hollie   (150.201.25.190) Tue Jul 29 10:13:24 PM EDT 2003
Yes, I will always hope!!

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:14:14 PM EDT 2003
That's what keeps me going!

Sue type 1  (216.221.81.98) Tue Jul 29 10:14:36 PM EDT 2003
I don't know many people with type 1

Sue type 1  (216.221.81.98) Tue Jul 29 10:15:44 PM EDT 2003
what kind of insulin are you on?

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:16:00 PM EDT 2003
I am on Humalin N and Humalog

Sue type 1  (216.221.81.98) Tue Jul 29 10:18:08 PM EDT 2003
I love Humalog!!!

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:18:47 PM EDT 2003
ya, humalog is nice.

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:19:34 PM EDT 2003
Mark your'e the first person I've seen in this room on those insulins - my daughter is on those too.

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:20:22 PM EDT 2003
cool. I want to switch to Lantus. But it is not avaiable here in canada yet.

sue type 1  (216.221.81.98) Tue Jul 29 10:21:28 PM EDT 2003
Mark I am Canadian as well, what province are you in ??

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:21:40 PM EDT 2003
hot alberta

Sue type 1  (216.221.81.98) Tue Jul 29 10:22:00 PM EDT 2003
do you have a cwd mail address ?

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:22:20 PM EDT 2003
Yes, it sounds good,doesn't it? But I've heard there is some concern over Lantus causing tumours.

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:22:20 PM EDT 2003
nope. I don't have one.

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:22:54 PM EDT 2003
ya, I just hate having to inject at night. I sometimes forget if I am busy.

Sue type 1  (216.221.81.98) Tue Jul 29 10:22:58 PM EDT 2003
I am in Ontario

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:23:17 PM EDT 2003
Sue, isn't there an adult - type 1 chat room also?

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:23:44 PM EDT 2003
cool. I have friends from Ontario. I am talking to one of them now.

Sue type 1  (216.221.81.98) Tue Jul 29 10:23:54 PM EDT 2003
are you twice a day with N at brkfst and supper?

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:24:00 PM EDT 2003
yes, there is a chatroom for adult type 1

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:24:17 PM EDT 2003
N in the morning and N at bed

Sue type 1  (216.221.81.98) Tue Jul 29 10:26:31 PM EDT 2003
the most popular room seems to be the Parents room

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:26:49 PM EDT 2003
ya, thats is the one I mostly talk in.

Sue type 1  (216.221.81.98) Tue Jul 29 10:27:33 PM EDT 2003
may I ask where in Ont your friend is?

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:28:39 PM EDT 2003
She is from Cambridge

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:30:08 PM EDT 2003
I'm a bit slow!!! I only just realised there are different rooms! What a dork.

Sue type 1  (216.221.81.98) Tue Jul 29 10:30:42 PM EDT 2003
hahaha  LOL 

Sue type 1  (216.221.81.98) Tue Jul 29 10:31:32 PM EDT 2003
funny I've never seen you in Parents room  Smile 

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:32:19 PM EDT 2003
oh, will I am in there.

Sue type 1  (216.221.81.98) Tue Jul 29 10:32:39 PM EDT 2003
is your friend a D like us ?

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:32:41 PM EDT 2003
Can I ask you both, from a non-diabetic point of view, what's so good about humalog?

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:32:43 PM EDT 2003
Hi

Jennifer(MA) Mom of Allyson age 8 dx in march  (4.64.206.104) Tue Jul 29 10:32:46 PM EDT 2003
hi

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:32:55 PM EDT 2003
nope. she is somewhat blind

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:33:38 PM EDT 2003
Hi Jennifer

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:34:09 PM EDT 2003
Hi Kim and Jennifer!

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:34:16 PM EDT 2003
Humaolg is wonderful, I like it cause it stats working in 15 mins and it os out of the system in 2 hours

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:35:00 PM EDT 2003
Austin is back on shots at the momment, and we are using Novolog which is like Humalog

Sue type 1  (216.221.81.98) Tue Jul 29 10:35:02 PM EDT 2003
Mel : it works alot faster than Reg

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:35:19 PM EDT 2003
for long acting he is on Lantus

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:36:15 PM EDT 2003
I dislike Reg alot

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:36:50 PM EDT 2003
So it's a lot more predictable?Kim why is Austin on shots ? And do you like Lantus?

Sue type 1  (216.221.81.98) Tue Jul 29 10:38:49 PM EDT 2003
Mark you still there ?

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:39:07 PM EDT 2003
yes, we are on shots just trying it out again, we are just switching back, and I love Lantus

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:39:08 PM EDT 2003
yep, I am still here

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:39:59 PM EDT 2003
it is just to much to disconnect when you want to swim, and then get back connected so you dont run high, so we are on shots and it is working great so far

Sue type 1  (216.221.81.98) Tue Jul 29 10:40:21 PM EDT 2003
what kind of glucometer do you use ?

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:41:06 PM EDT 2003
I have the acu-chek compact

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:41:16 PM EDT 2003
us?

Jennifer(MA) Mom of Allyson age 8 dx in march  (4.64.206.104) Tue Jul 29 10:41:27 PM EDT 2003
ally uses one touch ultra

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:41:37 PM EDT 2003
one touch ultra

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:41:46 PM EDT 2003
oh OK. I'm in New Zealand and we don't have Lantus here yet, we're way behind!! But I'd love to try it , and pumping.

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:42:27 PM EDT 2003
We don;t have lantus here yet. Worst part is it is made my a Canadian Company.

Sue type 1  (216.221.81.98) Tue Jul 29 10:42:43 PM EDT 2003
I love one touch ultra it is so fast!!!

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:43:10 PM EDT 2003
I am sure you will get the chance  Grin  You will love either one you get to try first

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:43:30 PM EDT 2003
That's typical Mark! Rolling Eyes 

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:43:56 PM EDT 2003
I like the acu-check compact because I don;t have to handle strips.

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:44:18 PM EDT 2003
Mark: we used that, and I did not care for it much

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:44:41 PM EDT 2003
Kim, We'll probably have to wait 10 years! It's very frustrating hearing about all the tecnology we don't have access to.

Sue type 1  (216.221.81.98) Tue Jul 29 10:44:56 PM EDT 2003
I have that one too Mark it is a goo feature

Sue type 1  (216.221.81.98) Tue Jul 29 10:45:11 PM EDT 2003
good

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:45:17 PM EDT 2003
I am sure it is, I hope it wont be 10 years, I am hoping for miracles by then..lol

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:46:21 PM EDT 2003
ME TOO!!! Grin 

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:46:23 PM EDT 2003
oh, it was way better then the first one. I had a acu-chek advantage. they are not that good.

Kim (VA) Mom of Austin, 5, dx'd at 1, pumping  (68.106.91.61) Tue Jul 29 10:47:10 PM EDT 2003
well guys I am heading to bed, I am tired, I hope all has a goodnight

Sue type 1  (216.221.81.98) Tue Jul 29 10:47:12 PM EDT 2003
I found that one did too much

Sue type 1  (216.221.81.98) Tue Jul 29 10:47:23 PM EDT 2003
bye Kim

Sue type 1  (216.221.81.98) Tue Jul 29 10:49:00 PM EDT 2003
Mark how many hrs behind Ont are you?

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 10:49:17 PM EDT 2003
Bye Kim, I'd better head off too, nice talking to you all, Bye.

Sue type 1  (216.221.81.98) Tue Jul 29 10:49:47 PM EDT 2003
is it 3 hrs same as BC ?

Sue type 1  (216.221.81.98) Tue Jul 29 10:49:56 PM EDT 2003
bye Mel

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:50:03 PM EDT 2003
I am 2 hours

Sue type 1  (216.221.81.98) Tue Jul 29 10:51:21 PM EDT 2003
so its 10 to 9 there?

Sue type 1  (216.221.81.98) Tue Jul 29 10:52:00 PM EDT 2003
cool

Sue type 1  (216.221.81.98) Tue Jul 29 10:52:59 PM EDT 2003
Mark are you also in Parents room now ?

Mark 24, dx'd at 21  (204.209.37.2) Tue Jul 29 10:53:13 PM EDT 2003
yeop, I am in there

Sue type 1  (216.221.81.98) Tue Jul 29 10:54:06 PM EDT 2003
ok bye nice meeting you

Susan Cory - 13 pumping  (205.188.208.6) Tue Jul 29 10:55:01 PM EDT 2003
Hello

Susan Cory - 13 pumping  (205.188.208.6) Tue Jul 29 10:56:10 PM EDT 2003
I have a hypoglycemia question.

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 11:01:22 PM EDT 2003
Susan are you there?

Susan   (205.188.208.6) Tue Jul 29 11:02:30 PM EDT 2003
back

Susan   (205.188.208.6) Tue Jul 29 11:03:04 PM EDT 2003
Hi Mel, are you still here?

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 11:04:01 PM EDT 2003
Hi. Seems like everybody has gone. I was just heading off,don't know if I can help - probably not!

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 11:07:22 PM EDT 2003
SUsan you still there?

Susan   (205.188.208.6) Tue Jul 29 11:08:53 PM EDT 2003
Yes

Susan   (205.188.208.6) Tue Jul 29 11:09:37 PM EDT 2003
I know a lot about the symptoms of hypo but need to know one more thing --- does it cause the heart to have an irregular rhythm?

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 11:11:49 PM EDT 2003
I really don't know, but it would seem logical to me, it must affect the heart somehow...???? Have you asked in the other chat rooms?

Susan   (205.188.208.6) Tue Jul 29 11:11:55 PM EDT 2003
Now where have all my good buddies gone? I NEED someone -- DH was hospitalized today.

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 11:12:18 PM EDT 2003
Someone will probably know.

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 11:13:27 PM EDT 2003
Who's DH Susan? I'm sorry to hear you've had an awful day.

Susan   (205.188.208.6) Tue Jul 29 11:13:40 PM EDT 2003
My grandson has type 1 and when his blood sugar goes low, he has a fast heart rate. My husband has hypoglycemia and today they said he had a heart attack due to irregular heart beats. Where is another chat room?

Susan   (205.188.208.6) Tue Jul 29 11:13:57 PM EDT 2003
DH --- is my husband.

Susan   (205.188.208.6) Tue Jul 29 11:16:53 PM EDT 2003
I have to go for now. If anyone comes online, reads my question and has an answer, I can be reached at Elifor43@aol.com Thanks

Mel Mum of Eilish, 6 dxd at 3  (202.27.176.157) Tue Jul 29 11:17:29 PM EDT 2003
I'm so sorry. You must be feeling awful. If you look up at the top of the page, where the Room, Update, and Show are, then scroll down until you find one. I hope everything turns out for you, sorry I can't help more.



                 
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