children with DIABETES - Research News and Information



		Research News and Information

Current Research News

11 May 2008

Dendritic cells in islets of Langerhans constitutively present ß cell-derived peptides bound to their class II MHC molecules. Free full text available in HTML and PDF formats. See also Suspected cause of type 1 diabetes caught "red-handed" for the first time.
Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with birthweight and maternal HbA(1c).
Metabolic Profile and Nitric Oxide Synthase Expression of Skeletal Muscle Fibers are Altered in Patients with Type 1 Diabetes.
Relation of Time of Introduction of Cow Milk Protein to an Infant and Risk of Type-1 Diabetes Mellitus. Free full text available in HTML and PDF formats. See also Link between early consumption of cows' milk and Type-1 diabetes.
4 May 2008

Fully Automated Closed-Loop Insulin Delivery Versus Semiautomated Hybrid Control in Pediatric Patients With Type 1 Diabetes Using an Artificial Pancreas.
Prevention of type 1 diabetes: the time has come.
Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization.
Vitamin D and the Diabetic Patient. Free registration required.
Genetic and humoral autoimmunity markers of type 1 diabetes: from theory to practice. Free Portuguese language full text available in HTML and PDF formats.
Has Time Come for New Goals in Human Islet Transplantation?
Combined Islet and Hematopoietic Stem Cell Allotransplantation: A Clinical Pilot Trial to Induce Chimerism and Graft Tolerance.
Islet Transplantation for Brittle Type 1 Diabetes: The UIC Protocol.
Glycated Albumin is a Better Indicator for Glucose Excursion than Glycated Hemoglobin in Type 1 and Type 2 Diabetes. Free full text available in PDF format.
Differences in Metabolites in Pain-Processing Brain Regions in Patients With Diabetes and Painful Neuropathy.
Heritability of proliferative diabetic retinopathy.
Intracellular signalling by C-peptide. Free full text available in HTML and PDF formats.
Potencial role of stem cell therapy in type 1 diabetes mellitus. Free full text available in HTML and PDF formats.
27 April 2008

Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes.
Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.
Fulminant type 1 diabetes as a model of nature to explore the role of C-peptide.
The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes.
Association analysis of the type 2 diabetes loci in type 1 diabetes.
Prevalence of atopy in children with type 1 diabetes mellitus, hepatitis B virus carriers, and healthy children: Role of T helper 1 (Th1)-type immune response.
Immunological efficacy of heat shock protein 60 peptide DiaPep277(TM) therapy in clinical type I diabetes.
Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. Free full text available in HTML and PDF formats.
Immunosuppression in islet transplantation. Free full text available in HTML and PDF formats.
Elevated Catalase And Heme Oxygenase-1 May Contribute To Improved Postischaemic Cardiac Function In Long-term Type 1 Diabetes.
20 April 2008

Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus.
Angiotensin-converting enzyme activity and cognitive impairment during hypoglycaemia in healthy humans.
The influence of autonomic neuropathy on cough reflex sensitivity in children with diabetes mellitus type 1. Free full text available in PDF format.
Diabetes-Enhanced Tumor Necrosis Factor-{alpha} Production Promotes Apoptosis and the Loss of Retinal Microvascular Cells in Type 1 and Type 2 Models of Diabetic Retinopathy.
Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort.
Postural blood pressure changes and associated factors in long-term Type 1 diabetes: Wisconsin Epidemiologic Study of Diabetic Retinopathy.
Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis.
Control of pancreatic beta-cell fate by insulin signaling: The sweet spot hypothesis.
Relation of Time of Introduction of Cow Milk Protein to an Infant and Risk of Type-1 Diabetes Mellitus.
13 April 2008

The Renal Hemodynamic Effect of Cyclooxygenase 2 Inhibition in Young Men and Women with Uncomplicated Type 1 Diabetes Mellitus.
Association between retinopathy, microalbuminuria and coronary perfusion in young patients with type 1 diabetes mellitus.
Effect Of Oral Amino Acid On Counterregulatory Responses And Cognitive Function During Insulin-induced Hypoglycemia In Non-diabetic And Type 1 Diabetic People.
6 April 2008

Altered Kinetics of Interleukin-6 and Other Inflammatory Mediators During Exercise in Children With Type 1 Diabetes.
Type 1 diabetes: can exercise impair the autoimmune event? The L-arginine/glutamine coupling hypothesis.
The Role of Advanced Glycation End Products in Progression and Complications of Diabetes.
Post-Meal Glucose Peaks at Home Associate with Carotid Intima-Media Thickness in Type 2 Diabetes.
Continuous, but Not Occasional, Oral Ethanol Intake Reduces the Success of Intraportal Transplanted Islets of Langerhans: An Experimental Study.
Biodritin microencapsulated human islets of langerhans and their potential for type 1 diabetes mellitus therapy.
Treatment of Diabetic Rats with Encapsulated Islets.
Ingested (oral) SIRS peptide 1-21 suppresses type 1 diabetes in NOD mice.
PAX4 Enhances Beta-Cell Differentiation of Human Embryonic Stem Cells. See also Stem cell breakthrough offers diabetes hope.
30 March 2008

Autologous umbilical cord blood infusion for type 1 diabetes.
Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population.
Incidence of children with slowly progressive form of type 1 diabetes detected by the urine glucose screening at schools in the Tokyo Metropolitan Area.
The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes.
The relationship between risk factors and mortality in type 1 diabetic patients in Europe, the EURODIAB Prospective Complications Study (PCS).
Having One Kidney Does Not Accelerate the Rate of Development of Diabetic Nephropathy Lesions in Type 1 Diabetic Patients.
Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy.
Improved Metabolic Control and Quality of Life in Seven Patients With Type 1 Diabetes Following Islet After Kidney Transplantation.
HLA sensitization in islet transplantation.
Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques.
23 March 2008

Effect of C-peptide on diabetic neuropathy in patients with type 1 diabetes.
Efficacy, safety and tolerability of pregabalin treatment of painful diabetic peripheral neuropathy: findings from 7 randomized, controlled trials across a range of doses.
Risk of microalbuminuria and progression to macroalbuminuria in a cohort with childhood onset type 1 diabetes: prospective observational study.
Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes.
Sex Hormone Binding Globulin and Testosterone in Individuals with Childhood Diabetes.
Trends in High-Risk HLA Susceptibility Genes Among Colorado Youth with Type 1 Diabetes.
Improved Metabolic Control and Quality of Life in Seven Patients With Type 1 Diabetes Following Islet After Kidney Transplantation.
16 March 2008

Vitamin D Supplementation in Early Childhood and Risk of Type 1 Diabetes: a Systematic Review and Meta-analysis. See also Vitamin D Lowers Diabetes Risk and Extra Vitamin D In Early Childhood Cuts Adult Diabetes Risk.
Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study.
Markers of endothelial dysfunction and inflammation in type 1 diabetic patients with or without diabetic nephropathy followed for 10 years: association with mortality and decline of glomerular filtration rate.
Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes.
The Arg16Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus.
A comparison of the levels of hepatocyte growth factor in serum in patients with type 1 diabetes mellitus with different stages of diabetic retinopathy.
Hormonal profile of diabetic men and the potential link to prostate cancer.
A Comparison of Protocols used to Generate Insulin-producing Cell Clusters from Mouse Embryonic Stem Cells.
Over 500 solitary pancreas transplants in nonuremic patients with brittle diabetes mellitus.
9 March 2008

A Microsphere-based Vaccine Prevents And Reverses New-onset Autoimmune Diabetes.
Noninvasive in vivo imaging of pancreatic islet cell biology. Free full text available through the DRI in PDF format. See also Diabetes Research Institute Develops Revolutionary Technique To Accelerate Research; First Ever "Living Window" Lets Scientists View Cell Activity, Processes in Real Time.
In Vitro Proliferation Of Cells Derived From Adult Human Beta Cells Revealed By Cell-lineage Tracing.
Serum alpha- and gamma-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus.
Serial Measurements of Cystatin C are More Accurate than Creatinine-based Methods in Detecting Declining Renal Function in Type 1 Diabetes.
Glucose variability, blood pressure and arterial stiffness in type 1 diabetes.
Short-term heart rate complexity is reduced in patients with type 1 diabetes mellitus.
Cutaneous Microvascular Dysfunction is associated with HLA-DQ in Youths with Type 1 Diabetes.
Abnormal NF-kappa-B Function Characterizes Human Type 1 Diabetes Dendritic Cells and Monocytes. See also Simple test to unlock the diabetes roulette in children.
Genetic Similarities Between LADA, Type 1 And Type 2 Diabetes.
2 March 2008

First-Trimester Human Fetal Pancreas Transplantation for Type 1 Diabetes Treatment.
A Risk Score for Type 1 Diabetes Derived From Autoantibody-Positive Participants in the Diabetes Prevention Trial–Type 1.
Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.
Endothelial dysfunction and microvascular complications in type 1 diabetes mellitus.
Oscillating glucose is more deleterious on endothelial function and oxidative stress than mean glucose in normals and type 2 diabetic patients.
Atrial natriuretic peptide prevents diabetes-induced endothelial dysfunction.
Bloodless Diabetes Monitoring; A new noninvasive tool uses electromagnetic waves to measure glucose levels.
A New Zealand linkage study examining the associations between glycosylated haemoglobin concentration and mortality.
Differential sensitivity of men and women to anorexigenic and memory improving effects of intranasal insulin. See also Insulin administered intranasally may lower food intake in men, improve memory in women.
24 February 2008

Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies.
Cytomegalovirus infection in early infancy: risk of induction and progression of autoimmunity associated with type 1 diabetes.
Winner of the 2007 Society for Thermal Medicine Young Investigator Award Fever-range whole body hyperthermia prevents the onset of type 1 diabetes in non-obese diabetic mice.
Generation of Insulin-producing Beta Cells from Stem Cells - Perspectives for Cell Therapy in Type 1 Diabetes.
17 February 2008

Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.
Environmental risk factors in prediction of childhood prediabetes. Free full text available in PDF format.
The islet autoantibody titres: their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus.
Glycemic Variability: Should we and can we prevent it?
Phenotype changes at the onset of type 1 diabetes in young adults from a Mediterranean area throughout the last decade.
High-Normal Serum Uric Acid Is Associated with Impaired Glomerular Filtration Rate in Nonproteinuric Patients with Type 1 Diabetes.
Glycosaminoglycans urinary excretion as a marker of the early stages of diabetic nephropathy and the disease progression.
ADVANCE Does Not Confirm ACCORD Results. See also Aggressive diabetes treatment affirmed in new study.
10 February 2008

Fully Automated Closed-Loop Insulin Delivery vs. Semi-Automated Hybrid Control in Pediatric Patients with Type 1 Diabetes using an Artificial Pancreas.
A unifying hypothesis on the development of type 1 diabetes and celiac disease: Gluten consumption may be a shared causative factor.
Association of Urinary Inflammatory Markers and Renal Decline in Microalbuminuric Type 1 Diabetics.
The effect of oral folic acid upon plasma homocysteine, endothelial function and oxidative stress in patients with type 1 diabetes and microalbuminuria.
Diagnostic potential of oxidative stress markers in children and adolescents with type 1 diabetes.
HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families.
A study of diabetes mellitus within a large sample of Australian twins.
Diabetes Study Partially Halted After Deaths (type 2 diabetes). For more information, see For Safety, NHLBI Changes Intensive Blood Sugar Treatment Strategy in Clinical Trial of Diabetes and Cardiovascular Disease, the ADA Position on the ACCORD study, and the ACCORD study web site. Compare also to Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes.
3 February 2008

Is C-peptide replacement the missing link for successful treatment of neurological complications in type 1 diabetes?
Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?
Time series analysis of ultraviolet B radiation and type 1 diabetes in Newfoundland.
Very high and increasing incidence of type 1 diabetes mellitus in Newfoundland and Labrador, Canada.
Maternal diet during pregnancy and islet autoimmunity in offspring.
The Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial -- Revisited.
Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model.
C-reactive Protein In Relation To The Development Of Microalbuminuria In Type 1 Diabetes: The Oxford Regional Prospective Study.
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults. See also Mild NSAID Hints at Type 2 Diabetes Prevention.
27 January 2008

Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism, cod liver oil and risk of type 1 diabetes.
Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus Using Serum and Functional Genomics.
The effects of metabolic control on oxidized low-density lipoprotein antibodies in children and adolescents with type 1 diabetes mellitus.
Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus.
Plasma {alpha}-defensin is associated with cardiovascular morbidity and mortality in type 1 diabetic patients. Free full text available in PDF format.
Interleukin-12 and tumour necrosis factor-alpha equilibrium is a prerequisite for clinical course free from late complications in children with type 1 diabetes mellitus.
Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002.
Transmission of type 1 diabetes by bone marrow transplantation: A case report.
Hemoglobin and overt nephropathy complications in type 1 diabetes.
Dietary Intake and the Development of the Metabolic Syndrome. The Atherosclerosis Risk in Communities Study. See also Burgers, Fries, and Diet Soda Are Recipe for Metabolic Syndrome.
13 January 2008

Vaccination against self to prevent autoimmune disease: the type 1 diabetes model.
Mutations in the Insulin Gene can Cause MODY and Autoantibody-Negative Type 1 Diabetes.
The Relationship Between Diabetes Mellitus and Traffic-Related Air Pollution.
AIR® Inhaled Insulin versus Subcutaneous Insulin: Pharmacokinetics, Glucodynamics, and Pulmonary Function in Asthma.
Relationship between plasma sialic acid and fibrinogen concentration and incident micro- and macrovascular complications in type 1 diabetes. The EURODIAB Prospective Complications Study (PCS).
Hypothesis-Ultraviolet-B Irradiance and Vitamin D Reduce the Risk of Viral Infections and thus Their Sequelae, Including Autoimmune Diseases and some Cancers.
6 January 2008

Extent of Beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus. Free full text available in HTML and PDF formats (see link in full text HTML).
Heterozygous Missense Mutations in the Insulin Gene are linked to Permanent Diabetes appearing in the Neonatal Period or in Early-Infancy: A report from the French ND Study Group.
Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort.
Nanoparticle strategies for the oral delivery of insulin.
30 December 2007

No change in apolipoprotein AI metabolism when subcutaneous insulin infusion is replaced by intraperitoneal insulin infusion in type 1 diabetic patients.
Insulin Mutation Screening in 1044 Patients with Diabetes: Mutations in the INS gene are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood.
Family-based analysis of vitamin D receptor gene polymorphisms and type 1 diabetes in the population of South Croatia.
Plasma concentration of asymmetric dimethylarginine (ADMA) predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy.
Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy.
The effects of type 1 diabetes on cerebral white matter.
23 December 2007

Effects of controlled hypoglycaemia on cardiac repolarisation in patients with type 1 diabetes.
"Type 1 on type 2" diabetes mellitus: autoimmune type 1 diabetes superimposed on established type 2 diabetes. Free full text available in PDF format.
Proinsulin C-peptide abrogates type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats.
Prevalence and determinants of elevated apolipoprotein B and dense LDL in youths with type 1 and type 2 diabetes. Free full text available in PDF format.
Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study.
A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland. Free full text available in PDF format.
Neonatal Formula Feeding Leads to Immunological Alterations in an Animal Model of Type 1 Diabetes.
16 December 2007

The Long Road to Beta Cells -- Quest for type 1 diabetes cure inches forward.
Knock Out, Knock In, Knock Down — Genetically Manipulated Mice and the Nobel Prize (PDF version) summarizes the process of removing and inserting genes into an animal's DNA, which is used extensively in research, including diabetes-related research.
Humoral immune responses of Type-1 Diabetes patients to M. avium subspecies paratuberculosis lend support to the infectious trigger hypothesis.
Regulated beta-cell regeneration in the adult mouse pancreas.
Treatment of type 1 diabetes by transplantation of bone-derived mesenchymal stem cells expressing human insulin gene: experiment with mice.
Defining pancreatic endocrine precursors and their descendants.
Proinsulin C-peptide Constricts Glomerular Afferent Arterioles in Diabetic Mice. A Potential Reno-Protective Mechanism.
The therapeutic potential of VEGF inhibition in diabetic microvascular complications.
The G53D Mutation in Kir6.2 (KCNJ11) is Associated with Neonatal Diabetes and Motor Dysfunction in Adulthood that is Improved with Sulfonylurea Therapy. Free full text available in PDF format.
9 December 2007

Proinsulin C-peptide -- the bioactive peptide with a huge promise.
A Risk Score for Type 1 Diabetes Derived from Autoantibody Positive Participants in The Diabetes Prevention Trial- Type 1.
Familiality of diabetes mellitus.
The occurrence and analysis of chosen risk factors of DKA among children with new onset of DMT1.
Double or hybrid diabetes associated with an increase in type 1 and type 2 diabetes in children and youths.
Epidemiology of childhood type 2 diabetes and obesity.
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. Free full text available in HTML and PDF formats.
B cell depletion: a novel therapy for autoimmune diabetes? Free full text available in HTML and PDF formats.
Incidence and trends of childhood Type 1 diabetes in Croatia from 1995 to 2003.
hsCRP protein in children and adolescents with diabetes type 1.
Proteomics and diabetic nephropathy.
Induction of immune tolerance to facilitate beta cell regeneration in type 1 diabetes.
Reduced Immunogenicety of First Trimester Human Fetal Pancreas.
Analysis of SNPs Identifies Major Type 1A Diabetes Locus Telomeric of the MHC.
2 December 2007

Increasing GLP-1-induced ß-cell Proliferation By Silencing The Negative Regulators Of Signaling CREM And DUSP14.
Murine Anti-Thymocyte Globulin Therapy Alters Disease Progression in NOD Mice by a Time Dependent Induction of Immunoregulation.
Novel human protein networks of genetic interactions in type 1 diabetes.
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes. Free full text available in PDF format.
Parental country of birth is a major determinant of childhood type 1 diabetes in Sweden.
Seasonality of month of birth differs between type 1 diabetes patients with pronounced beta-cell autoimmunity and individuals with lesser or no beta-cell autoimmunity.
Relationship of highly sensitive C-reactive protein and lipid levels in adolescents with type 1 diabetes mellitus.
Oxidative Stress and the JNK Pathway are Involved in the Development of Type 1 and Type 2 Diabetes.
Skin Autofluorescence: A Tool to Identify Type 2 Diabetic Patients at Risk for Developing Microvascular Complications.
Proteinuria disappears promptly after simultaneous kidney-pancreas transplantation in nephrotic diabetic patients with near-normal GFR.
RAGE and Experimental Diabetic Neuropathy.
25 November 2007

Family history of diabetes, autoimmunity, and risk factors for cardiovascular disease among children with diabetes in the SEARCH for Diabetes in Youth Study.
The islet autoantibody titres: their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus.
Increased TLR2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Pro-inflammatory state. Free full text available in PDF format.
Essential roles of TGF-{beta} in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells. Free full text available in PDF format.
18 November 2007

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.
Sex-specific association of the human PTPN22 1858T-allele with type 1 diabetes.
A Risk Score for Type 1 Diabetes Derived from Autoantibody Positive Participants in The Diabetes Prevention Trial- Type 1.
Uncomplicated type 1 diabetes and preclinical left ventricular myocardial dysfunction: Insights from echocardiography and exercise cardiac performance evaluation.
Progression of coronary artery calcium in type 1 diabetes mellitus.
An Insulin Infusion Advisory System for Type 1 Diabetes Patients based on Non-Linear Model Predictive Control Methods.
Detection of Hypoglycemic Episodes in Children with Type 1 Diabetes using an Optimal Bayesian Neural Network Algorithm.
Prediction of glucose excursions under uncertain parameters and food intake in intensive insulin therapy for type 1 diabetes mellitus.
A Communication and Information Technology Infrastructure for Real Time Monitoring and Management of Type 1 Diabetes Patients.
Attenuation of Counterregulatory Responses to Recurrent Hypoglycemia by Active Thalamic Inhibition: A Mechanism for Hypoglycemia-Associated Autonomic Failure.
High Prevalence of Type 2 Diabetes and Pre-Diabetes in Adult Offspring of Women with Gestational Diabetes Mellitus or Type 1 Diabetes – The Role of Intrauterine Hyperglycemia.
Impaired glucose balance and subtypes of diabetes mellitus revealed in intravenous glucose tolerance test.
Potential risk of porcine endogenous retrovirus cross-species transmission in neonatal pig islets under xenotransplanted condition.
11 November 2007

Glucagon-like-peptide-1 inhibits blood-brain glucose transfer in humans.
Prevalence of vitamin D receptor gene polymorphism in a Uruguayan population and its relation to type 1 diabetes mellitus.
Pro-inflammatory Variants of DRB1 and RAGE Genes Are Associated with Susceptibility to Pediatric Type 1 Diabetes: A New Hypothesis on the Adaptive Role of Autoimmunity.
Distribution of neuropeptide Y Leu7Pro polymorphism in patients with type 1 diabetes and diabetic nephropathy among Swedish and American populations.
Comparative therapeutic effects of orally administered 1,25-dihydroxyvitamin D(3) and 1alpha-hydroxyvitamin D(3) on type-1 diabetes in non-obese diabetic mice fed a normal-calcaemic diet.
Pancreatic Islet Cell Transplant for Treatment of Diabetes.
Pancreas-Kidney and Pancreas Transplantation for the Treatment of Diabetes Mellitus.
Induction of Robust Diabetes Resistance and Prevention of Recurrent Type 1 Diabetes Following Islet Transplantation by Gene Therapy.
Epitope Analysis of GAD65 Binding in both Cord Blood and at the Time of Clinical Diagnosis of Childhood Type 1 Diabetes.
The role of virus infections in the pathogenesis of type 1 diabetes--a case report.
4 November 2007

Early infant feeding and risk of type 1 diabetes mellitus-a nationwide population-based case-control study in pre-school children.
Low-risk HLA genotype in Type 1 diabetes is associated with less destruction of pancreatic B-cells 12 months after diagnosis.
Occurrence of enterovirus RNA in serum of children with newly diagnosed type 1 diabetes and islet cell autoantibody-positive subjects in a population with a low incidence of type 1 diabetes.
Islet cell autoantibodies in African patients with Type 1 and Type 2 diabetes in Dar es Salaam Tanzania: a cross sectional study. Free full text available in PDF format.
Stem cell genes may provide medicine's dream ticket includes a discussion of the work of enGene, Inc., which is working on a genetic engineering cure for type 1 diabetes.
Hematopoietic Mixed Chimerism Derived From Allogeneic Embryonic Stem Cells Prevents Autoimmune Diabetes Mellitus In Nod Mice.
Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.
Allogeneic islet transplantation.
Partial Pancreatectomy In Adult Humans Does Not Provoke Beta Cell Regeneration.
Simultaneous islet-kidney vs pancreas-kidney transplantation in type 1 diabetes mellitus: a 5 year single centre follow-up.
Cardiovascular impairment in children, adolescents, and young adults with type 1 diabetes mellitus (T1DM).
Burning mouth syndrome and peripheral neuropathy in patients with type 1 diabetes mellitus.
Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes.
Understanding the pathology and mechanisms of type I diabetic bone loss.
Detection of a Meal Using Continuous Glucose Monitoring (CGM): Implications for an Artificial ß-cell.
Inflammatory cytokines in insulin-treated patients with type 2 diabetes.
Menin Controls Growth of Pancreatic ß-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus.
Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heart.
28 October 2007

Immune intervention at diagnosis--should we treat children to preserve beta-cell function?
Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice.
Putative Delays in Interstitial Fluid (ISF) Glucose Kinetics Can Be Attributed to the Glucose Sensing Systems Used to Measure Them Rather Than the Delay in ISF Glucose Itself.
Worldwide childhood type 1 diabetes incidence--what can we learn from epidemiology?
Differential diagnosis of type 1 diabetes: which genetic syndromes need to be considered?
Identifying children at particular risk of long-term diabetes complications.
Sequence of progression of albuminuria and decreased GFR in persons with type 1 diabetes: a cohort study.
Doppler ultrasonography imaging of hemodynamic alteration of retrobulbar circulation in type 1 diabetic children and adolescents without retinopathy.
Captopril Inhibits Capillary Degeneration in the Early Stages of Diabetic Retinopathy.
Insulin Resistance And Progression To Type 1 Diabetes In The European Nicotinamide Diabetes Intervention Trial (ENDIT).
Insulin administration may trigger pancreatic beta-cell destruction in patients with type 2 diabetes.
Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease.
21 October 2007

Type 1 diabetes intervention trials 2007: where are we and where are we going?
Pancreas and islet cell transplantation in diabetes.
Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques. See also Cross-species transplant in rhesus macaques is step toward diabetes cure for humans.
Induction of insulin secretion in engineered liver cells by nitric oxide. Free full text available in PDF format.
Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method.
The effect of birth order and parental age on the risk of type 1 and 2 diabetes among young adults.
Abnormal T-cell reactivities in childhood inflammatory demyelinating disease and type 1 diabetes.
Protein restriction for diabetic renal disease.
Robust Parameter Estimation in a Model for Glucose Kinetics in Type 1 Diabetes Subjects.
14 October 2007

Differential anti-diabetic efficacy of incretin agonists vs. DPP-4 inhibition in high fat fed mice.
Beta-cell replacement in immunosuppressed recipients: old and new clinical indications.
Functional waning of naturally-occurring CD4+ regulatory T cells contributes to the onset of autoimmune diabetes.
Pluripotency Redux — Advances in Stem-Cell Research. See also Interview with Douglas Melton on the promise and limitations of recent advances in stem-cell research.
Highly poly(ethylene) glycolylated islets improve long-term islet allograft survival without immunosuppressive medication.
Inhaled insulin using AERx insulin Diabetes Management System (AERx iDMS).
Hyperplastic islets observed in "reversed" NOD mice treated without hematopoietic cells.
Mesenchymal Stem Cells Cooperate with Bone Marrow Cells in Therapy of Diabetes.
Novel Effectors of Directed and ngn3 Mediated Differentiation of Mouse Embryonic Stem Cells into Endocrine Pancreas Progenitors.
Encapsulation of porcine islets permits extended culture time and insulin independence in spontaneously diabetic BB rats.
7 October 2007

Inhibition of PKCepsilon Improves Glucose-Stimulated Insulin Secretion and Reduces Insulin Clearance. See also Proinsulin maturation, misfolding, and proteotoxicity and Sabotage in the insulin factory? Botched production of insulin molecule may kill pancreas cells and lead to diabetes, U-M study finds.
Solving a critical part of the insulin puzzle. See also Aussie scientists make diabetes breakthrough.
SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B. Free full text available in HTML and PDF formats.
Fatty Acids And Insulin Modulate Myocardial Substrate Metabolism In Humans With Type 1 Diabetes Mellitus.
Multiple SOD1/SFRS15 variants are associated with the development and progression of diabetic nephropathy: The DCCT/EDIC Genetics study.
Cardiovascular disease risk prediction in type 1 diabetes: Accounting for the differences.
Pancreatic scintigraphy with 99mTc-interleukin-2 at diagnosis of type 1 diabetes and after 1 year of nicotinamide therapy.
No increased incidence of diabetes in antidepressant users.
30 September 2007

Omega-3 Polyunsaturated Fatty Acid Intake and Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes. See also Omega-3s may protect children from diabetes and Omega-3s fight diabetes.
Early mortality in EURODIAB population-based cohorts of type 1 diabetes diagnosed in childhood since 1989. Free full text available in HTML and PDF formats.
Glycaemic control and antibody status among patients with newly diagnosed Type 1 diabetes.
Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study.
Environmental causes of type 1 diabetes.
Presence of residual beta cells and co-existing islet autoimmunity in the NOD mouse during longstanding diabetes: a combined histochemical and immunohistochemical study.
New sources of pancreatic beta cells.
Revascularization and remodelling of pancreatic islets grafted under the kidney capsule.
Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies.
Homocysteine and diabetic retinopathy.
23 September 2007

Prediction of the clinical remission using the C-peptide level in type 1 diabetes in children.
Familial Risk Factors for Microvascular Complications And Differential Male-Female Risk in a Large Cohort of American Families with Type 1 Diabetes. Free full text available in PDF format.
Defective function of the Fas apoptotic pathway in type 1 diabetes mellitus correlates with age at onset.
Quality of life after islet transplant: impact of the number of islet infusions and metabolic outcome.
Development and preclinical assessment of a bioartificial pancreas.
Animal models of spontaneous autoimmune disease: type 1 diabetes in the nonobese diabetic mouse.
Arterial hypertension exacerbates oxidative stress in early diabetic retinopathy.
16 September 2007

Beta Cell transplantation and immunosuppression: can't live with it, can't live without it.
Early Nutrition and Risk of Type 1 Diabetes Mellitus - A Nationwide Case-control Study in Preschool Children.
The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design.
Impairment of skin capillary recruitment precedes chronic complications in patients with type 1 diabetes.
Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children.
Human islets derived from donors after cardiac death are fully biofunctional.
Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways.
Beta-cell replacement and regeneration: Strategies of cell-based therapy for type 1 diabetes mellitus.
9 September 2007

Recovery from diabetes in mice by ß cell regeneration. Free full text available in HTML and PDF formats.
Prediction of type 1 diabetes among siblings of affected children and in the general population.
Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis.
Circulating CD4+CD25 high regulatory T cells and natural killer T cells in children with newly diagnosed type 1 diabetes or with diabetes-associated autoantibodies.
CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes.
Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients with Type 1 Diabetes and Their Role in Microvascular Complications.
The Role of Low Energy Expenditure and Sitting on Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease.
Association Between Low-Grade Systemic Inflammation and Type 2 Diabetes Mellitus Among Men and Women from the ATTICA Study.
2 September 2007

HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population.
Expression of cholera toxin B–proinsulin fusion protein in lettuce and tobacco chloroplasts – oral administration protects against development of insulitis in non-obese diabetic mice. See also Insulin Grown in Plants Relieves Diabetes in Mice; UCF Study Holds Promise for Humans and Local Professor Begins Human Trials For Diabetes Cure.
Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes.
Vessel wall stiffness in Type 1 diabetes, and the central hemodynamic effects of acute hypoglycemia.
Plasma endothelin response to acute hypoglycaemia in adults with Type 1 diabetes.
Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction.
19 August 2007

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Length of gestation and gender are associated with HLA genotypes at risk for Type 1 diabetes (Italian DIABFIN 3).
Epidemiology and genetic risk of type 1 diabetes among children in Aragon community, Spain.
Short- and long-term glycaemic control and the state of the renin system in type 1 diabetes mellitus.
12 August 2007

Evidence of Increased Inflammation and Monocytic Activity in Patients with Type 1 Diabetes: plausible role in Microvascular Complications.
Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice.
Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives.
Evidence for a Role of Superoxide Generation in Glucose Induced ß-cell Dysfunction In Vivo.
Non-invasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes.
Polymorphism of bovine beta-casein and its potential effect on human health is the full text in PDF of an article referenced last week and explores the hypothesis that certain cows' milk may be contributing to the increase in type 1 diabetes and other illnesses.
5 August 2007

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.
Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 mAb by enhancing recovery of {beta} cells.
Impact of Oxidative Stress on the Endothelial Dysfunction of Children and Adolescents With Type 1 Diabetes Mellitus: Protection by Superoxide Dismutase?
Rotavirus infections and development of type 1 diabetes: an evasive conundrum.
IGF-1 and leptin associate with fetal HDL-cholesterol at birth: examination in offspring of mothers with type 1 diabetes.
Influence of glycemic variables on hemoglobin A1c.
Polymorphism of bovine beta-casein and its potential effect on human health.
Immunoregulatory dendritic cells to prevent and reverse new-onset Type 1 diabetes mellitus.
29 July 2007

Oxidative stress in childhood type 1 diabetes: Results from a study covering the first 20 years of evolution.
Prevalence and prognostic implications of the metabolic syndrome in community-based patients with type 1 diabetes: The Fremantle Diabetes Study.
Presence of GAD Antibodies During Gestational Diabetes Mellitus Predicts Type 1 Diabetes.
The Effect of Medical Therapy and Islet Cell Transplantation on Diabetic Nephropathy: An Interim Report.
Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey.
22 July 2007

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. See also Uncovered: New Gene Linked To Type 1 Diabetes In Children, USA and Gene Discovered For Type 1 Diabetes In Children.
Carotid intima-media thickness in pediatric type 1 diabetes patients.
Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes.
Renal hemodynamic changes and renal functional reserve in children with type I diabetes mellitus.
The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey.
Advanced Glycation End Products (AGEs) and Cardiovascular Disease (CVD) in Diabetes.
The hemoglobin glycation index is not an independent predictor of the risk of microvascular complications in the Diabetes Control and Complications Trial.
Estimated prevalence of peripheral neuropathy and associated pain in adults with diabetes in France.
Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes.
Simvastatin protects against multiple low dose streptozotocin induced type 1 diabetes in CD-1 mice and recurrence of disease in non obese diabetic mice. Free full text available in PDF format.
The vicious cycle of apoptotic beta-cell death in type 1 diabetes.
15 July 2007

Diabetic nephropathy in 27,805 children, adolescents and adults with type 1 diabetes: effect of diabetes duration, HbA1c, hypertension, dyslipidemia, diabetes onset and gender.
Early changes in glomerular size selectivity in young adults with type 1 diabetes and retinopathy. Results from the Diabetes Incidence Study in Sweden.
Association of VEGF-1499C-->T polymorphism with diabetic nephropathy in type 1 diabetes mellitus.
Higher Prevalence of Elevated Albumin Excretion in Youth with Type 2 than Type 1 Diabetes: The SEARCH for Diabetes in Youth Study.
The effect of exercise on the absorption of inhaled human insulin via the AERx® iDMS in people with type 1 diabetes.
8 July 2007

Generation of Insulin-producing Cells From Human Bone Marrow Mesenchymal Stem Cells By Genetic Manipulation.
Maternal Psychological Reaction to Newborn Genetic Screening for Type 1 Diabetes.
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. See also CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans.
Australian children and adolescents with type 1 diabetes have low vitamin D levels. Also available in PDF format (see page 3).
T cell immunomodulation-the Holy Grail of therapeutic tolerance.
Prevalence of autoimmune diseases in islet transplant candidates with severe hypoglycaemia and glycaemic lability: previously undiagnosed coeliac and autoimmune thyroid disease is identified by screening.
Glucagon, in Concert with Insulin, Supports the Postabsorptive Plasma Glucose Concentration in Humans.
Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetes.
Lower heart rate variability is associated with higher plasma concentrations of IL-6 in type 1 diabetes.
1 July 2007

Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy.
Telmisartan Shows an Equivalent Effect of Vitamin C in Further Improving Endothelial Dysfunction After Glycemia Normalization in Type 1 Diabetes.
Effect of oral insulin on insulin autoantibody levels in the Diabetes Prevention Trial Type 1 oral insulin study.
The effect of ramipril therapy on cytokines and parameters of incipient diabetic nephropathy in patients with type 1 diabetes mellitus.
Prospective Study of Type 1 and Type 2 Diabetes and Risk of Stroke Subtypes; The Nurses' Health Study.
Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury.
24 June 2007

Exenatide blocks JAK1-STAT1 in pancreatic beta cells.
Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus.
Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis. Free full text available in PDF format.
Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development.
Organ specific autoantibodies in preclinical and early clinical type 1 diabetes in Turkey.
Influence of stressful life events on the onset of Type 1 diabetes in childhood.
17 June 2007

Pancreatic islet transplantation, what has been achieved since Edmonton break-through.
Participant and Parent Experiences in the Parenteral Insulin Arm of the Diabetes Prevention Trial for Type 1 Diabetes.
Islet autoantibody development during follow-up of high-risk children from the general Norwegian population from three months of age: Design and early results from the MIDIA study.
Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes.
Interferons induce an antiviral state in human pancreatic islet cells.
Differentiation of transplanted microencapsulated fetal pancreatic cells.
Diabetes Patient Successfully Transplanted in World-first DiabeCell® Trial. See also LCT awarded world-first IANZ accreditation for xenotransplantation laboratory and Pig cells transplanted into patient.
Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance. See also European researchers poke away at Type 1 diabetes with effective vaccination in mice.
Improved Monitoring of the Hyperglycemic State in Type 1 Diabetes Patients by Use of the Glycoalbumin/HbA1c Ratio.
10 June 2007

Stressful life events and psychological dysfunctions before the onset of type 1 diabetes mellitus.
Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume.
Decreased blood dendritic cell counts in type 1 diabetic children.
Simple switch turns cells embryonic; Technique removes need for eggs or embryos.
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Free full text available in HTML and PDF formats.
3 June 2007

Major increase in Type 1 diabetes-no support for the Accelerator Hypothesis.
Engineered enteroendocrine cells secrete insulin in response to glucose and reverse hyperglycemia in diabetic mice.
Association between Glycosylated Hemoglobin Level and Cardiovascular and All-Cause Mortality in Type 1 Diabetes.
Oxidant stress, immune dysregulation, and vascular function in type I diabetes.
Meta-analysis of the effects of n-3 polyunsaturated fatty acids on lipoproteins and other emerging lipid cardiovascular risk markers in patients with type 2 diabetes.
A method to predict the metabolic effects of changes in insulin treatment in subgroups of a large population based patient cohort.
The Role of Insulin Resistance in Predicting the Progression to Type 1 Diabetes.
Thiazolidinediones and Heart Failure: A Teleo-Analysis.
Length of gestation and gender are associated with HLA genotypes at risk for Type 1 diabetes (Italian DIABFIN 3).

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