What organizations are involved in the islet cell replacement research and is this the most promising program today to cure Type 1 diabetics?
Islet cell replacement research is going on in many Universities, mostly in the U.S.; but also in Canada, Australia, Britain and Sweden; and this is at both the applied level as well as in the basic science. You could get an idea of the distribution by going to your nearest medical library and looking up in a MEDLINE® search where most of the papers are coming from.
At the moment, intraportal autografts seem to work well in non-diabetic cases where the pancreas has to be removed for pancreatitis. The islets are separated out and returned. Attempts to treat Type 1 Diabetes with islet cell transplants have so far failed. Animal trials with encapsulated porcine xenografts avoid immunosuppression; but have a long way to go before the implants can be completely protected against the host's immune system and the graft coatings can be made more robust. Even then, successful transplants will not constitute a 'cure' as the disorder of the immune system will remain. Fortunately for the immediate future new substituted insulins, more sophisticated pumps and some promising new modulations of the immune system promise alternative routes to immaculate control.
Original posting 13 Oct 96
Last Updated: Tuesday April 06, 2010 15:08:52
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.