From a physician:
My patient develops hives to NPH, but not Regular. So far we have been premedicating him with Benadryl [an antihistamine]. Have you found other creative solutions other than Lente and Ultralente? Could it be the preservatives?
As you imply, there's probably something in the NPH that could be responsible for the allergic reaction: usually, it's thought to be the Protamine. Things to try:
- Switch from NPH to Lente. They have approximately the same effect and approximately the same duration of action, and a unit-for-unit switch may solve the problem.
- Switch from Lilly brand to Novo-Nordisk, or from Novo-Nordisk to Lilly. There's the remote chance it's something in the buffers that might be different between the two different manufacturers.
- Call the manufacturers and ask their advice: their phone numbers are in the PDR (Physician's Desk Reference).
Original posting 18 Feb 97
Last Updated: Tuesday April 06, 2010 15:08:52
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