From Wichita, Kansas, USA:
Does being overweight really add to the cause of diabetes? Why is that?
Obesity increase the likelihood of Type 2 Diabetes and the explanation runs something like this. Fat tissue require about three times as much insulin for basal metabolism as does muscle tissue. Obesity therefore increases the demand for insulin and raises serum insulin levels. This in turn downregulates the insulin receptors (i.e., makes them even more insensitive to insulin). The result of this cycle is an increased demand for insulin production to the point that production is insufficient to keep blood glucose at normal levels. New drugs like troglitazone [Rezulin® brand] are designed to break this chain by increasing receptor sensitivity to insulin. Losing weight of course reduces demand for insulin.
Original posting 9 Mar 97
Last Updated: Tuesday April 06, 2010 15:08:54
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.