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Question:

I need more information on "demyelination" disease. I have a family member with multiple sclerosis and diabetes and would like to know more on the subject.

Answer:

Multiple Sclerosis is a chronic progressive remitting/relapsing disorder of the central nervous system which is now recognized as being, like Type 1 Diabetes, one of the group of autoimmune disorders. As with Type 1 Diabetes, susceptibility is characterized by certain cell surface protein patterns called HLA-DQ. Recent attempts at treatment have centered around a variety of attempts to restore a normal balance to the immune response by giving interferon and trials of stem cell transplants. Perhaps the best promise of success has come from giving oral antigen, in this case myelin. There seems to be no specific association with diabetes other than a random one for two relatively common conditions except that optic neuritis is more likely to occur in cases of multiple sclerosis who also have diabetes.

As you can probably imagine, there is an enormous literature on the demyelinating diseases, much more than can be condensed into an e-mail. So, if you are looking for detail and feel you can grasp the technical jargon, you should get help from your nearest medical library, something your doctor could help with, or try to access MEDLINE.

DO'B

Original posting 14 Sep 97

  
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Last Updated: Tuesday April 06, 2010 15:08:54
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