Can too much insulin trigger the production of glucose? I used to take 8 U Humalog at lunchtime and two hours later my readings often were in the 12-15 mmol/l range. I tried 10 units, 12 units and even 14 units which didn't make any difference. Once I mistakingly took 6 units and all afternoon my readings were perfect! Today I take 6 units and only if I eat less than usual do I see values above 10 mmol/l.
If too much insulin causes hypoglycemia, then the liver releases glucose first from stored liver glycogen (glycogenolysis) and after a while as de novo synthesis from substrates such as gluconeogenic amino acids (gluconeogenesis). This can often happen after eating with lispro insulin [Humalog®] (as you describe) due to the faster peak absorption rate from injection sites compared with Regular insulin. If you consider this, you can then easily understand the high values you register 2 hours after eating and why a reduced dose does keep good values over the afternoon. I'm wondering whether the shorter waning time of lispro compared to Regular could be implied in any upsurge of blood sugar late afternoon if not mixed with NPH.
Original posting 1 Apr 1998
Posted to Hypoglycemia
Last Updated: Tuesday April 06, 2010 15:08:58
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.