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From Kentucky, USA:

My daughter, a ten year old, has been diagnosed with type 1 for almost 10 months. Her endocrinologist has said that she is still in the honeymoon stage due to her amounts of insulin dosage per day. Is there anything that could possibly be done to help prolong the honeymoon stage or regenerate her pancreas?


There have been many, many, trials to see if it could not be possible to prolong the honeymoon period. Sadly, but not surprisingly, they have none of them been successful except in one instance where the drug turned out to be damaging to the kidneys. That so many things seemed to work in that much-used experimental animal, the NOD mouse, it was a disappointment that done of them did the same in humans. Part of the problem of course is that by the time clinical diabetes develops, over 90% of islet function has already been lost and the remainder already compromised. For this reason, recent trials have focused more on diagnosing diabetes before it is clinically apparent using family history, genetic typing and the presence in blood of anti-insulin and other antibodies. Nicotinamide, a B vitamin, has been used in New Zealand and is the subject of a big trial in Europe and Canada called ENDIT and in the U.S. there is a corresponding trial of small doses of insulin, given either by mouth or subcutaneous injection called DPT-1. Both trials have some years to go before the value of these regimens can be assessed.


Original posting 30 Jan 1999
Posted to Honeymoon and Research: Causes and Prevention


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