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Question:

From Québec, Canada:

What is the relation between degree of hyperopia and the sugar level in the blood?

Answer:

Sudden and fluctuating changes in refraction are well recognized feature of hyperglycemia, and usually are readily reversible. A tendency towards myopia has always been associated with elevations in blood glucose: several studies on the effect of acute and chronic changes in serum glucose concentration pointed out that higher levels of serum glucose concentration produce myopia and lower levels produce hyperopia, and that these changes are related to changes in the optical properties of the crystalline lens, secondary to changes in the rate of incorporation of glucose into the lens.

Recently however, a hyperopic concept has been advanced, to suggest that hyperglycemia may produce hyperopia (Eva et al., 1982; Fledelius, 1987). It must be remembered that the crystalline lens has two main compartments, the cortex and the nucleus, with different biochemical and optical properties. It may be presumed that hyperopia is the consequence of accumulation of osmotically active substance in the outer cortex of the lens, causing the refractive index to increase relatively and to approximate that of nucleus. Instead, if the refractive index of the lens as a whole, cortex and nucleus, becomes too high, index myopia ensues. Also, a decrease in the physiological tone of the ciliary muscle may play role in some patients showing hyperopia.

MS

Original posting 25 Apr 1999
Posted to Complications

  
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Last Updated: Tuesday April 06, 2010 15:09:02
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