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Question: From North Carolina, USA: Can one develop resistance to long acting insulin (NPH)? My morning blood sugars are high. During the day when I take Humalog, they are more stable. Increasing the night time shot does not seem to help. Answer: Not at all. I think what you observe (called the dawn phenomenon) is quite common due to relatively low doses of insulin over the first part of the nighttime secondary to the short half-life of the supper dose of lispro insulin [Humalog® brand]. It sounds as you should first check whether: The NPH is injected at a sufficient dose and at bedtime; The 3:00 A.M. blood sugar is okay, to be sure that you avoid the Somogyi Effect and then adjust your regimen accordingly, under the supervision of your diabetes team. MS DTQ-19990305174336 Original posting 9 Jun 1999 Posted to Hyperglycemia and DKA

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