From Providence, Rhode Island, USA:
Why can't you keep insulin in the freezer and then let is thaw? Does the insulin molecule denature? What is the temperature range that is okay in order for the protein to remain active?
Regular short acting insulin is a solution of microcrystalline insulin in a phosphate buffer with added zinc and bacteriostatic. The manufacturer gives specific instructions that the product should not be frozen. If this happens, some of the insulin may come out of solution and not be redissolved on thawing: it is not denatured. The same is true of the more complex forms of long acting insulin. Insulins are stable for 28 days if kept between 36 and 86 degrees Fahrenheit.
Original posting 10 Jun 1999
Posted to Insulin
Last Updated: Tuesday April 06, 2010 15:09:04
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.