From a physician in Massachusetts, USA:
My 4 year old grandson has type 1 diabetes. Please advise which of these insulins may be mixed together in the same syringe for his injection, without adversely affecting each other: Humalog, NPH, Ultralente, Regular.
Officially approved by Eli Lilly:
Not "officially approved" but published in studies:
- You can mix Humalog with NPH or Ultralente in the same syringe.
- You can mix Regular with NPH or Ultralente in the same syringe
Officially not recommended
- Mixing Regular and Humalog together in the same syringe
- Mixing NPH with Ultralente in the same syringe. According to Eli Lilly the phosphate in the NPH theoretically could precipitate the zinc in the Ultralente. From what I have been told, this is a theoretical concern that has never actually been reported, Humalog by the way also has phosphate and has been extensively studied and approved to mix in the same syringe with Ultralente. I have never been able to get a clear explanation from Eli Lilly why mixing NPH and Ultralente should be a problem but not mixing Humalog and Ultralente.
Here is the mixing guidelines in chart form:
Insulin Mixing Guide Insulin Humalog Regular NPH Lente UltraLente Humalog Yes* Yes Yes Yes Regular Yes* Yes Yes Yes NPH Yes Yes No No Lente Yes Yes No Yes UltraLente Yes Yes No Yes * Not officially approved but published in studies.
I personally have many patients mixing Regular, Humalog, Lente, and Ultralente in the same syringe with no problem. I am aware of many physicians who have their patients mix NPH and Ultralente (with Regular or Humalog ) in the same syringe with no problem.
I suggest that patients or parents ask their own doctor what he or she recommends.
Original posting 29 Jun 1999
Posted to Insulin
Last Updated: Tuesday April 06, 2010 15:09:06
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