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Question: From California, USA: If one is using an insulin pump with Lispro and the insulin supply is terminated, then how long does it take before ketoacidosis is a severe problem? Answer: Probably in about 2 to 3 hours. Lispro insulin [Humalog® brand] only lasts a short while, and there is some delay because of the depot under the skin, but I wouldn't want to have a lack of insulin for than about an hour. Whenever there is lack of insulin delivery from the pump, you should check blood glucose levels about every 1 - 2 hours to monitor what's going on. That way, you can supplement with an injection if you need to. You should always have a vial of short-acting insulin (Lispro or Regular) and a syringe with you. SS DTQ-19990423143338 Original posting 30 Jun 1999 Posted to Insulin Pumps and Hyperglycemia and DKA

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