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Question:

Is Moduretic (a thiazide) or Atenolol (a beta blocker) contraindicated in Type 2 diabetes? I thought both of these would make blood sugars rise.

Answer:

You are correct in supposing that both the thiazide drugs and the beta blockers without intrinsic sympathomimetic activity increase glucose intolerance in Type 2 diabetes. This is especially so when they are used together; but the problem can be circumvented by using ACE inhibitors as a first antihypertensive drug and by reducing the thiazide dose to as little as 6.25 mg hydrochlorothiazide a day. The mechanisms are complex, but you can find several reports by searching in PubMed.

DOB

DTQ-20000423203220
Original posting 1 Jul 2000
Posted to Other Medications

  
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Last Updated: Tuesday April 06, 2010 15:09:10
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