From Tonawanda, New York, USA:
My three-and-one-half year old son was diagnosed with type 1 diabetes one year ago. I have Polycystic Ovarian Syndrome (PCOS), psoriasis, and psoriatic arthritis. When I was seven months pregnant with him, we did the three-hour glucose tolerance test, and I was considered to have "borderline" gestational diabetes (GDM), controlled by diet alone. Would my having PCOS and/or psoriasis make him more prone to carry the genetic make up for type 1? I understand that they believe they have recently found a gene that predisposes women to have PCOS, and I am wondering about the connection.
The short answer to your question is that neither PCOS nor psoriasis is thought to predispose any children to autoimmune diabetes or indeed any other kind of diabetes in that age group. It is interesting though that some people with PCOS have ovarian antibodies, and, whilst the incidence of these antibodies is no greater than in a control population, it still leaves open the possibility that in some instances those antibodies may reflect autoimmune damage. Psoriasis is associated with chromosomal changes on the long arm of chromosome 11 which is also the site of genes involved in autoimmune diabetes. Perhaps, when the human genome data is fully available, there will be more insights into these possible links.
Original posting 27 Jul 2000
Posted to Genetics and Heredity
Last Updated: Tuesday April 06, 2010 15:09:12
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.