advertisement
 

  Back to Ask the Diabetes Team Ask the Diabetes Team
Question:

From California, USA:

My 14 year old son was diagnosed with diabetes four months ago. His islet cell antibodies were negative but his GAD-65 was 4.3. He is doing extremely well with one unit of Ultralente at breakfast and dinner combined with one unit of Humalog with every meal. Are there any precautions available to prolong this honeymoon period and are there any complications to be aware of from his GAD-65 results?

Answer:

I showed your e-mail to the doctor who does our antibody testing and he was not able to comment on the figure for anti GAD because it was on a different scale to ours, but I will assume that it was positive. There have been many attempts to prolong the honeymoon period and big trials are going on in the US and in Europe to see if either small doses of insulin by injection or orally or the vitamin nicotinamide will do this. In the past, a number of other drugs have been tried and the only one that was successful was with a medication called cyclosporin. However, after a year or so, there was a significant risk of kidney damage. The only other successful attempt that I know of has been the use of nicotinamide in antibody positive school children in New Zealand. In this study, daily nicotinamide seems to have deferred insulin dependence in about 60% for as long as eight years, but, if the vitamin was stopped, clinical diabetes soon followed. In trials where insulin was already needed, nicotinamide had no effect.

The only important complication to avoid at this stage is severe hypoglycemia at a time when you are trying to balance diet, exercise and insulin dose so as to keep blood sugars as near to normal as possible. I am sure that this is something that your diabetes team has already talked to you about.

DOB

DTQ-20000328162705
Original posting 31 Jul 2000
Posted to Honeymoon

  
advertisement


                 
  Home Return to Top

Last Updated: Tuesday April 06, 2010 15:09:12
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.

This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2015. Comments and Feedback.