From Virginia, USA:
I have several questions which I hope you might answer:
- In type 1 diabetes, the pancreas cells are destroyed due to various viruses, GAD, etc. Is the difference between type 1A and type1B is that one is due to a virus, and one is not?
- Can a type 1A state be permanent, but have no antibodies in the blood? (not due to trauma)
- Could the antibodies that caused type 1A diabetes spontaneously disappear?
- Could regenerated cells (from the same person) be re-transplanted into a type 1 with no antibodies with no further damage to the cells?
- The difference between type 1A and type 1B diabetes is that, in the former, there are one or more specific antibodies in the blood at the time of diagnosis.
- Yes, antibodies may disappear after the insulin producing cells have been destroyed.
- Assuming that insulin producing cells from early in the course of type 1A diabetes could be biopsied and cultured (not possible at this time), they would be destroyed on reintroduction by the continuing autoimmune process which is vested in certain lymphocytes not in the presence of antibodies. This approach has been tried with the partial transplantation of the pancreas between identical twins, and it did not succeed for the above reason.
Last Updated: Tuesday April 06, 2010 15:09:18
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2017. Comments and Feedback.