From London, England:
What are the chances of a child getting diabetes if the father has insulin dependent diabetes and marries his first cousin? Are the risks greater?
The chances of a child getting diabetes when the father has type 1 is slightly more than when the mother is affected, and in a Caucasian family would be around 7%. You might however get a clearer estimate if you both were DQB typed for susceptibility genes, but even then the environmental trigger would be imponderable. There is a National trial in England called ENDIT, which is assessing the role of the vitamin nicotinamide in delaying insulin dependence in high risk infants. If the occasion arises, you might talk to your doctor about this. At any event, the treatment of type 1A or autoimmune in the young is advancing so rapidly that this small a risk would not seem to justify avoiding having a wanted child.
Original posting 29 Dec 2000
Posted to Genetics and Heredity
Last Updated: Tuesday April 06, 2010 15:09:18
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2017. Comments and Feedback.