From Auckland, New Zealand:
Has there ever been a study to see if there is any association between diabetes and primary amyloidosis?
There is an association between amyloidosis and type 2 diabetes which seems to be activated through a substance called IAPP or Islet Amyloid PolyPeptide, and there is an animal model in the cat. The mechanism is still not understood, but you might get more insight from an article, Pancreatic islet with mellitus. Implication for therapeutic strategy (Int J Pancreatol, 1995 Aug;18(1):7-14; Oosterwijk C, Hoppener JW, van Hulst KL, Lips CJ). Also, there is a review of the problem in the New England Journal of Medicine, August 2000, vol 343, page 411 which any hospital librarian could help you find. It seems though to be more a mechanical interference with beta cell function rather than an increase in insulin resistance due to an increase in IAPP.
Original posting 22 Feb 2001
Posted to Other Illnesses
Last Updated: Tuesday April 06, 2010 15:09:17
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by Children With Diabetes, Inc, which is responsible for its contents.
© Children with Diabetes, Inc. 1995-2014. Comments and Feedback.