From Windsor, Ontario, Canada:
I have 14 year old friends who are identical twins. One twin has had type 1 diabetes for many years, but the other does not have diabetes. If diabetes is a genetic disorder, and identical twins have identical genetic information, why does one twin have diabetes and not the other?
In the older studies, it had been shown that there was concordance for diabetes in only about 30% of cases of identical twins. This was the basis of arguments for the relative importance of environmental triggers over genetic predisposition. However, the follow up period was limited to less than 10 years from the onset of diabetes in the affected twin. When follow-up was extended to forty years, the concordance for clinical diabetes had more than doubled, and, in addition, an even higher percentage of cases had evidence of islet cell autoimmunity. in the form of antibodies.
Original posting 27 Feb 2001
Posted to Genetics and Heredity
Last Updated: Tuesday April 06, 2010 15:09:18
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents.
© Children with Diabetes, Inc. 1995-2015. Comments and Feedback.