Back to Ask the Diabetes Team Ask the Diabetes Team

From Tiburon, California, USA:

Is Actos safe? I've heard that the earlier version caused liver damage.


Actos [pioglitazone] is the trade name for a drug in a class of medications called thiazolidinediones. These agents lower glucose by improving your body's response to the circulating insulin levels present. The earliest of the drugs in this class of medications was Rezulin [troglitazone]. The drug was effective in lowering glucose but was associated with liver damage in some patients. Eventually, Rezulin was withdrawn from the market.

The drugs of this class currently on the market have not been associated with a high frequency of liver damage. However, the Food and Drug Association has recommended regular liver enzyme testing with these medications for at least a year. These drugs have also been shown to increase the collection of fluid in the body in patients at risk of heart failure. Of interest, these medications may also have benefits in decreasing the propensity to form clots in blood vessel and the development of hardening of the arteries.


Original posting 28 Jul 2001
Posted to Pills for Diabetes


  Home Return to Top

Last Updated: Tuesday April 06, 2010 15:09:24
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.

This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2015. Comments and Feedback.