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Question:

From El Paso, Texas, USA:

Do thiazolidinediones cause a so-called fatty liver?

Answer:

Rezulin [Rezulin, a pill for type 2 diabetes] was withdrawn from the market because of a rare, but potentially fatal, risk of drug-induced liver failure. The mechanism of the liver failure was not predictable. The other medications from the same group that are currently on the market, Actos [pioglitazone] and Avandia [rosiglitazone], do not have the same risk for the liver dysfunction.

In communicating this information, it is important to note that patients with poorly controlled typeá2 diabetes develop fatty liver, and treatment with drugs like Rezulin have been shown to improve the fatty liver.

JTL

DTQ-ONCGBDM20011001
Original posting 9 Oct 2001
Posted to Pills for Diabetes

  
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Last Updated: Tuesday April 06, 2010 15:09:26
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