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Question: From London, United Kingdom: I am 15 years old and as an infant, I had a sub-total pancreatectomy because of nesidioblastosis which has left me with type 1 diabetes. Are there any tests I need to go through before I can have children? If I had children in the future would they be at a higher risk of developing nesidioblastosis? Answer: The recommendations to you would be the same as for anyone else with type 1 diabetes. Essentially, you should be in good glucose control prior to conception and maintain that throughout the pregnancy. You should also be taking extra folic acid (1 mg/day) to reduce the risk of neural tube defects. Nesidioblastosis is an autosomal recessive disorder. This means that if you have a child with someone who carries the gene, but is not affected, then the risk of a child with nesidioblastosis is 50% and of being a carrier (no disease) is also 50%. However, if you have a child with someone who does not carry the defect, then your child would only be a carrier. Nesidioblastosis is rare (I do not know the incidence in the population), thus the chances of having a child with someone who is a carrier is low. I would strongly suggest that you meet with a genetic counselor before you decide to have children to discuss this further. OWJ DTQ-20011116201128A Original posting 22 Nov 2001 Posted to Family Planning

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Last Updated: Tuesday April 06, 2010 15:09:27
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