From Honolulu, Hawaii, USA:
I was told that the A1c is the long term measure of hyperglycemia and that any blood glucose above 120 mg/dl [mmol/L] triggers the A1c to be above normal. Does it not then hypothesize that if daily blood glucose readings on average are considerably within the hypo-glycemic range that this would thereby balance the fewer hyper- glycemic daily blood glucose levels?
Hemoglobin A1c is an integrated average of blood glucose levels over the life of the red blood cell -- approximately 120 days. However, in fact, the more recent blood glucose levels can have more influence than older ones so it is likely a better average of the past 30-60 days or so. Hypoglycemic values would tend to balance hyperglycemic values if they occurred with equal frequency and duration -- but the hypos tend to be more transient compared to the number of hyperglycemic episodes because of the relative difficulty of providing adequate insulin -- especially in the postprandial time period. Nevertheless, A1c is the best objective long term measure of glucose control, but cannot be used for individual or daily insulin dose decisions since it is a time-average of blood glucose levels.
Original posting 17 Dec 2001
Posted to A1c, Glycohemoglobin, HgbA1c
Last Updated: Tuesday April 06, 2010 15:09:30
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.