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From Onsted, Michigan, USA:

What is the typical standard deviation for the A1c test?


If you are using standard deviation as a measure of the reliability of a hemoglobin A1c test, the best figures are those from the American College of Pathology EXCEL proficiency testing program. In a recent report on 109 laboratories all using the DCA 2000 program, the standard deviation on a sample mean of 5.93% was 0.3 which gives a variance (S.D./mean x 100) of 5% and 95% confidence limits of about twice this. The second most commonly used method however had a variance of more than 10%, and at the other end of the scale, in an individual laboratory where a single person does all the tests and maintains the instruments the variance may be less than 3.0%.


[Editor's comment: See also HbA1c Measurement and The National Glycohemoglobin Standardization Program. JSH]

Original posting 12 Feb 2002
Posted to A1c, Glycohemoglobin, HgbA1c


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Last Updated: Tuesday April 06, 2010 15:09:30
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