From Santa Rosa, California, USA:
I know there have been some studies on endotoxin LPS in people with type 1 diabetes. What can you tell me about this?
This is a rather complex topic to be distilled understandably. Put very simply though, LPS or lipopolysaccharide is a molecule that is a component of bacterial endotoxin and a constituent of bacterial and other cell walls. Its relevance to type 1A (autoimmune) diabetes is that it has the capacity to enhance the production of the cytokine IL-12p40 by suitably primed antigen presenting cells. The IL-p40 is then important in stimulating the production of the sensitised lymphocytes which are the effector cells in autoimmune damage to the islet cells. Perhaps much more important is that the understanding of this sequence of events has led to the genetic engineering of cultured insulinoma cells so that they can become resistant to IL-12p40 and thus become more effective surrogate islet cells for transplantation.
Original posting 18 Oct 2003
Posted to Other
Last Updated: Tuesday April 06, 2010 15:09:52
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.