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Question: From India: Can there be resistance or restriction of insulin's transcapillary movement due to any disorder resulting into decreased effect of insulin? If yes, which disorders are related to it? Can variations in pressure in vessels especially oncotic or vascular wall inflammation or swelling of vascular walls or circulating cells cause such resistances? Answer: One condition that comes to mind is the presence of atherosclerotic vascular disease. Insulin induces vasodilitation in skeletal muscle in a nitric oxide-dependant fashion. This allows higher flows and increased delivery of glucose to the tissues. It is known that inflammation related to vascular disease will decrease nitric oxide generation in the vessels and decrease this flow-mediated glucose disposal. JTL DTQ-20061123010256 Original posting 28 Nov 2006 Posted to Insulin

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			Jump to a new section --[ Getting Around ]-- Home Page What's New Guide to CWD Help with Error Messages Index Privacy Policy Search Site Map --[ People ]-- Family Support Network Adults with Diabetes Care Photos Chat Rooms Conferences Kids with Diabetes Parents Parent Humor Scholarships and Financial Aid Grandparents Humorous Tidbits Jobs Mailing Lists CWD Forums Poetry and Art Videos Polls Quilt for Life Surveys Blogs --[ Clinic ]-- Ask the Diabetes Team Alternate Site Testing Alternative Treatments Care Suggestions CWD Español Diabetes Basics Diabetes at School 504 Plans Diabetes Camps Diabetes Dictionary Insulin Pumps Nutrition Podcasts Presentations Products Product Marketplace Sports Studies Warning Signs --[ Sources ]-- News and Information Diabetes Advocacy Links to Other Web Sites Press Releases Regional Information Services Support Groups --[ Feedback ]-- About CWD Get CWD Products Advertise Awards Contribute Your Experiences Disclaimer Letters to the Editor Logos and Linking Share our Brochures

Last Updated: Tue Nov 28 11:00:52 2006
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