Can there be resistance or restriction of insulin's transcapillary movement due to any disorder resulting into decreased effect of insulin? If yes, which disorders are related to it?
Can variations in pressure in vessels especially oncotic or vascular wall inflammation or swelling of vascular walls or circulating cells cause such resistances?
One condition that comes to mind is the presence of atherosclerotic vascular disease. Insulin induces vasodilitation in skeletal muscle in a nitric oxide-dependant fashion. This allows higher flows and increased delivery of glucose to the tissues. It is known that inflammation related to vascular disease will decrease nitric oxide generation in the vessels and decrease this flow-mediated glucose disposal.
Original posting 28 Nov 2006
Posted to Insulin
Last Updated: Tuesday April 06, 2010 15:10:10
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.