What are the possible glycogen storing and breakdown abnormalities in type 2 diabetics who are not yet on medications, on just oral medicines and on oral medicines and insulin? Can more and continual insulin exposure (endo or exogenous), either due to persisting hyperglycemia or added, interfere in the normal storage and breakdown/usageof glycogen? Why is glycogenic heptameghaly?
Diabetes is usually associated with inappropriate glucose output from the liver. That means that there is inappropriately elevated glycogen breakdown and gluconeogenesis causing the increased glucose output. Insulin works to decrease these pathways in the liver. I am not sure what you mean by glycogenic hepatomegaly. There are some inborn errors of metabolism diseases associated with inactivity of enzymes where glycogen cannot be broken down, increases in the liver, and causes an enlargement in the liver.
Last Updated: Tuesday April 06, 2010 15:10:12
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents.
© Children with Diabetes, Inc. 1995-2015. Comments and Feedback.