Can persistent hyperglycemia and insulin resistance in type 2 diabetics be due to decreased transcapillary movements of insulin (resulted from cell swellings in blood and in vascular walls) by hypotonicity of blood due to elevated glucose or otherwise? Since the insulin molecule is bigger, does it result in decreased insulin exposure to target cells instead of commonly thought decreased sensitiveness of insulin? This looks quite relevant and simple reasoning to insulin resistance or persisting hyperglycemia.
The major effect of insulin resistance is a post-receptor event. Your hypothesis has not been shown to be a major cause of insulin resistance. The movement of insulin to its receptor on the surface of target cells is not a rate-limiting step in insulin's effects.
Last Updated: Tuesday April 06, 2010 15:10:11
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by Children With Diabetes, Inc, which is responsible for its contents.
© Children with Diabetes, Inc. 1995-2013. Comments and Feedback.