From Indianapolis, Indiana, USA:
We have a son with type 1 diabetes. Recently, our four-year-old daughter tested positive for GAD and MIAA auto-antibodies through a TrialNet study. She has no symptoms at all of diabetes. Does this mean her body is already attacking her beta cells? Will she most likely get diabetes? We are having a glucose tolerance test in two weeks and will be doing Phase 2 of the study. We have been given information on Phase 3 of the trial, oral insulin versus placebo. From everything I have seen on the net, it looked like the oral insulin DPT-1 failed, but the literature that the doctor gave me seems to suggest that there is evidence that the oral insulin helped delay onset and reduce insulin requirements. I wanted to put her in the trial (if she qualifies), but not if it has already proven to make no difference. What have you heard about it? I really just want some more opinions.
A positive antibody test indicates increased risk. You should then have more specific genetic studies to see if the genes she has are the same, similar and how similar, to your other child. This also helps to stratify risks. What happens with the more specific testing would be important and what happens over time to these titers will also be important. You should go back to the research team and ask these detailed questions to help you decide if she should participate, what the risks are and what odds are currently known for success or failure. Currently, our research belief is that we maybe able to postpone, but not totally stop, diabetes. Newer medications may be better, but with more unknown short- and long-term side effects/risks.
Original posting 4 Aug 2007
Posted to Research: Causes and Prevention
Last Updated: Tuesday April 06, 2010 15:10:12
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents.
© Children with Diabetes, Inc. 1995-2015. Comments and Feedback.