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Question: From India: Can we consider insulin resistance as a tolerance or resistance to previous excessive or increased exposure of sugar or/and insulin in type 2 diabetics? Is such previous excessive or more exposure common up to some stages after getting type 2 diabetes? As such, can decreasing excessive intake of foods, exercising, withdrawal of oral diabetic medicines and injected insulin for some time can help in reversing insulin resistance? I mean reversing insulin resistance, but not just normalizing of glucose level temporarily. Answer: Resistance can happen both ways. For instance, patients with type 1 diabetes are insulin resistant. They are exposed to high insulin levels with exogenous insulin therapy. This results in down-regulation of insulin receptors. We routinely clamp patients with good control with type 1 diabetes and they have insulin resistance, compared to age-matched healthy subjects. People with type 2 diabetes have insulin resistance as a result of a post-receptor defect in insulin signal transduction. It is clear that short-term food restriction or weight loss will decrease insulin resistance. However, there is no eliminating insulin resistance as a pathophysiologic process. The property is genetic and can be seen in first degree relatives of people with type 2 diabetes who are otherwise healthy. It can be decreased with healthy lifestyle. JTL DTQ-20070820063751 Original posting 15 Sep 2007 Posted to Type 2

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			Jump to a new section --[ Getting Around ]-- Home Page What's New Privacy Policy Search --[ People ]-- Family Support Network Adults with Diabetes Care Photos Chat Rooms Conferences Kids with Diabetes Parents Parent Humor Scholarships and Financial Aid Grandparents Humorous Tidbits Jobs Mailing Lists CWD Forums Poetry and Art Videos Polls Quilt for Life Surveys Blogs --[ Clinic ]-- Ask the Diabetes Team Alternate Site Testing Alternative Treatments Care Suggestions CWD Español Diabetes Basics Diabetes at School 504 Plans Diabetes Camps Diabetes Dictionary Insulin Pumps Nutrition Podcasts Presentations Products Product Marketplace Sports Studies Warning Signs --[ Sources ]-- News and Information Diabetes Advocacy Links to Other Web Sites Press Releases Regional Information Services Support Groups --[ Feedback ]-- About CWD Advertise Awards Contribute Your Experiences Disclaimer Letters to the Editor Logos and Linking Share our Brochures

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