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Question: From India: My query is related to C-Peptide test interpretation which doctors generally ignore for a patient as they feel does not hold any importance. My C-Peptide at diagnosis was 390 pmol (206 - 934). I am 32 years old and often had fasting blood sugars in the 270 mg/dl [15.0 mmol/L] range. I'm unable to derive any interpretations from this. My doctor says I have type 2, which I believe should be supported by hyperinsulinism/with insulin resistance, so my C-Peptide should be quite high. Similarly, in type 1, C-Peptide values are negligible, which again is not supported. Also, I was not very overweight nor lean, with a BMI of 27 before diagnosis I have several questions. If my fasting C-Peptide is 390 pmol (206 - 934), what does this signify in a diabetic patient as beta cells will be working in the bolus mode at a sugar level of 270 mg/dl [15.0 mmol/L]? Another point is that persistent blood glucose levels over 150 mg/dl [8.3 mmol/L] contribute to glucose desensitization/toxicity which will not reflect true C-Peptide. Should I get my C-Peptide level tested again to know the real values? After three months of insulin initially, I'm on metformin 500, twice a day, and exercise, with fasting blood sugars of 80 mg/dl [4.4 mmol/L] to 100 mg/dl [5.6 mmol/L] and postprandial blood sugars no higher than 140 mg/dl [7.8 mmol/L] for seven months. Is C-Peptide a predictor that the subject will be insulin dependent in future? If that is, then which data should I look upon, C-Peptide at diagnosis or after treatment? Otherwise, my GAD Antibodies are -ve, but I have not been tested for ICA/IAA 2. What do you suggest? Answer: Several points about C-Peptide in the diagnosis of type 1 versus type 2 diabetes. Most patients in clinical studies with type 1 diabetes have been confirmed by using a mixed meal challenge that raises blood sugars and C-Peptide levels are still negligible. For patients with type 2 diabetes, C-Peptide levels may not be appropriate for level of hyperglycemia, but they are still measurable. This would be irrespective of glucose toxicity from elevated blood sugars. JTL DTQ-20080203055357 Original posting 6 Feb 2008 Posted to Other

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			Jump to a new section --[ Getting Around ]-- Home Page What's New Privacy Policy Search --[ People ]-- Family Support Network Adults with Diabetes Care Photos Chat Rooms Conferences Kids with Diabetes Parents Parent Humor Scholarships and Financial Aid Grandparents Humorous Tidbits Jobs Mailing Lists CWD Forums Poetry and Art Videos Polls Quilt for Life Surveys Blogs --[ Clinic ]-- Ask the Diabetes Team Alternate Site Testing Alternative Treatments Care Suggestions CWD Español Diabetes Basics Diabetes at School 504 Plans Diabetes Camps Diabetes Dictionary Insulin Pumps Nutrition Podcasts Presentations Products Product Marketplace Sports Studies Warning Signs --[ Sources ]-- News and Information Diabetes Advocacy Links to Other Web Sites Press Releases Regional Information Services Support Groups --[ Feedback ]-- About CWD Advertise Awards Contribute Your Experiences Disclaimer Letters to the Editor Logos and Linking Share our Brochures

Last Updated: Tuesday April 06, 2010 15:10:14
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