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Question: From India: Pancreas/beta cells can either be overused or underused in type 2 diabetes. How can its overuse and under use impact or damage it? Answer: I prefer to think of type 2 diabetes to be associated with insulin resistance (overactive insulin secretion) and inappropriately low insulin secretion (underactive insulin secretion). Most people believe that both components exist coincidentally at the time of diagnosis. It is not that overuse or underused damages beta cells. It is that the abnormalities are already there at diagnosis. Many people have insulin resistance but only a few people have diabetes. It is thought that most of the genetic abnormalities determined to date reflect on impaired insulin secretion. Therefore, it is as if those pre-determined to have diabetes in the face of insulin resistance are going to be those with the genetic defects to ramp up insulin secretion. JTL DTQ-20090108230950 Original posting 18 Jan 2009 Posted to Other and Type 2

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			Jump to a new section --[ Getting Around ]-- Home Page What's New Privacy Policy Search --[ People ]-- Family Support Network Adults with Diabetes Care Photos Chat Rooms Conferences Kids with Diabetes Parents Parent Humor Scholarships and Financial Aid Grandparents Humorous Tidbits Jobs Mailing Lists CWD Forums Poetry and Art Videos Polls Quilt for Life Surveys Blogs --[ Clinic ]-- Ask the Diabetes Team Alternate Site Testing Alternative Treatments Care Suggestions CWD Español Diabetes Basics Diabetes at School 504 Plans Diabetes Camps Diabetes Dictionary Insulin Pumps Nutrition Podcasts Presentations Products Product Marketplace Sports Studies Warning Signs --[ Sources ]-- News and Information Diabetes Advocacy Links to Other Web Sites Press Releases Regional Information Services Support Groups --[ Feedback ]-- About CWD Advertise Awards Contribute Your Experiences Disclaimer Letters to the Editor Logos and Linking Share our Brochures

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