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Question:

From India:

Can long acting insulins cause downregulation of insulin's receptors due to their prolonged and continual exposure in comparison to short acting insulin due to decreased insulin oscillations and degradation?

Answer:

Theoretically, they could. However, I am no sure that has been worked out. I do not know at what concentration of the analog this becomes a more prominent issue. I do not see increased insulin resistance with insulin glargine compared to NPH.

JTL

DTQ-20091117063812
Original posting 19 Dec 2009
Posted to Insulin

  
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Last Updated: Tuesday April 06, 2010 15:10:20
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