Can long acting insulins cause downregulation of insulin's receptors due to their prolonged and continual exposure in comparison to short acting insulin due to decreased insulin oscillations and degradation?
Theoretically, they could. However, I am no sure that has been worked out. I do not know at what concentration of the analog this becomes a more prominent issue. I do not see increased insulin resistance with insulin glargine compared to NPH.
Original posting 19 Dec 2009
Posted to Insulin
Last Updated: Tuesday April 06, 2010 15:10:20
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.