Can long acting insulins cause downregulation of insulin's receptors due to their prolonged and continual exposure in comparison to short acting insulin due to decreased insulin oscillations and degradation?
Theoretically, they could. However, I am no sure that has been worked out. I do not know at what concentration of the analog this becomes a more prominent issue. I do not see increased insulin resistance with insulin glargine compared to NPH.
Original posting 19 Dec 2009
Posted to Insulin
Last Updated: Tuesday April 06, 2010 15:10:20
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