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		Research News from 2012	Jump to a new section --[ Getting Around ]-- Home Page What's New Privacy Policy Search --[ People ]-- Family Support Network Adults with Diabetes Care Photos Chat Rooms Conferences Kids with Diabetes Parents Parent Humor Scholarships and Financial Aid Grandparents Humorous Tidbits Jobs Mailing Lists CWD Forums Poetry and Art Videos Polls Quilt for Life Surveys Blogs --[ Clinic ]-- Ask the Diabetes Team Alternate Site Testing Alternative Treatments Care Suggestions CWD Español Diabetes Basics Diabetes at School 504 Plans Diabetes Camps Diabetes Dictionary Insulin Pumps Nutrition Podcasts Presentations Products Product Marketplace Sports Studies Warning Signs --[ Sources ]-- News and Information Diabetes Advocacy Links to Other Web Sites Press Releases Regional Information Services Support Groups --[ Feedback ]-- About CWD Advertise Awards Contribute Your Experiences Disclaimer Letters to the Editor Logos and Linking Share our Brochures

Research News From 2012

23 May 2012

1. Type 1 diabetes associated and tissue transglutaminase autoantibodies in patients without type 1 diabetes and coeliac disease with confirmed viral infections.
2. Association between carotid intima-media thickness, buccodental status, and glycemic control in pediatric type 1 diabetes.
3. Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection.
4. The Effect of Type 2 Diabetes Risk Loci on Insulin Requirements in Type 1 Diabetes.
5. Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady state conditions in type 1 diabetes.
6. Decreased GAD(65) -specific Th1/Tc1 phenotype in children with Type 1 diabetes treated with GAD-alum.
7. Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes. For more information, visit the JDRF NPOD web site.

   16 May 2012

8. The Increasing Onset of Type 1 Diabetes in Children.
9. Emerging Effects of Early Environmental Factors over Genetic Background for Type 1 Diabetes Susceptibility: Evidence from a Nationwide Italian Twin Study.
10. Incidence of Type 1 Diabetes in Childhood before and after the Reunification of Germany - an Analysis of Epidemiological Data, 1960-2006.
11. In Vivo Imaging of Endogenous Pancreatic beta-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET.
12. In vitro and in vivo testing of glucose-responsive insulin-delivery microdevices in diabetic rats.
13. Mixed Chimerism and Growth Factors Augment beta Cell Regeneration and Reverse Late-Stage Type 1 Diabetes.
14. Etiopathogenesis of insulin autoimmunity. Free full text available in HTML and PDF formats.

    9 May 2012

15. Prevention of Type 1A Diabetes. Free full text available in PDF format.
16. Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes. Free full text available in HTML and PDF formats.
17. Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes. Free full text available in HTML and PDF formats.
18. Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice. Free full text available in HTML and PDF formats.

    2 May 2012

19. Challenges in diagnosing type 1 diabetes in different populations. Free full text available in HTML and PDF formats.
20. Clinical performance of a device that applies local heat to the insulin infusion site: a crossover study.
21. Clinical requirements for closed-loop control systems.
22. The identifiable virtual patient model: comparison of simulation and clinical closed-loop study results.

    25 April 2012

23. Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice.
24. Hematopoietic stem cell transplantation for curing children with severe autoimmune diseases: Is this a valid option? (See also hematopoietic stem cell transplantation in Wikipedia.)

    18 April 2012

25. Potent Induction Immunotherapy Promotes Long-Term Insulin Independence After Islet Transplantation in Type 1 Diabetes.
26. Human Insulin Secreted From Insulinogenic Xenograft Restores Normoglycemia in Type I Diabetic Mice without Immunosuppression.
27. An Actor-Critic based controller for glucose regulation in type 1 diabetes.
28. Birth weight in newborn infants with different diabetes-associated HLA genotypes in three neighboring countries: Finland, Estonia and Russian Karelia.
29. Infection as a cause of type 1 diabetes?
30. High-density lipoprotein subspecies between patients with type 1 diabetes and type 2 diabetes without / with intensive insulin therapy.

    11 April 2012

31. Reversal of Diabetes in Mice with a Bioengineered Islet Implant Incorporating a Type I Collagen Hydrogel and Sustained Release of Vascular Endothelial Growth Factor.
32. Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice. See also Engineered Gut Bacteria Reverse Type 1 Diabetes in Experimental Mice.
33. Antigen targets of type 1 diabetes autoimmunity. Free full text available in HTML and PDF formats.
34. Pleiotropic action of proinsulin C-peptide.
35. Enhancing the Accuracy of Subcutaneous Glucose Sensors: A Real-time Deconvolution-based Approach.
36. The effects of folic acid on markers of endothelial function in patients with type 1 diabetes mellitus.
37. Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: The TEDDY Study.

    4 April 2012

38. Neighborhood context and incidence of type 1 diabetes: The SEARCH for Diabetes in Youth Study.
39. Longitudinal trends in use and costs of prescription medication in patients with type 1 diabetes: The impact of renal disease.
40. Prevalence of gastroparesis-related symptoms in an unselected cohort of patients with Type 1 diabetes.

    28 March 2012

41. Restoring insulin production for type 1 diabetes.
42. Improved Preservation of Residual Beta Cell Function by Atorvastatin in Patients with Recent Onset Type 1 Diabetes and High CRP Levels (DIATOR Trial). Free full text available in HTML and PDF via link.
43. Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk.
44. Improving cellular function and immune protection via layer-by-layer nanocoating of pancreatic islet beta-cell spheroids cocultured with mesenchymal stem cells.
45. The Effects of Long-Term Oral Benfotiamine Supplementation on Peripheral Nerve Function and Inflammatory Markers in Patients With Type 1 Diabetes.
46. Gastric Autoimmunity in Children and Adolescents with Type 1 Diabetes: A Prospective Study.

    21 March 2012

47. Maternal Enterovirus Infection as a Risk Factor for Type 1 Diabetes in the Exposed Offspring.
48. Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants. See also Collaborative Study from the Diabetes Research Institute Federation and The Cure Alliance Shows that Stem Cells Can Replace Powerful Anti-Rejection Drug to Prevent Rejection and Improve Outcome in Transplant Recipients.
49. Autologous Hematopoietic Stem Cell Transplantation Modulates Immunocompetent Cells and Improves beta-Cell Function in Chinese Patients with New Onset of Type 1 Diabetes.
50. Glucose-stimulated insulin secretion of various mesenchymal stem cells after insulin-producing cell differentiation.
51. Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria.
52. Costs of paediatric diabetes care in Germany: current situation and comparison with the year 2000.
53. Distinguishing type 2 diabetes from type 1 diabetes in african american and Hispanic american pediatric patients. Free full text available in HTML and PDF formats.

    14 March 2012

54. Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study.
55. Effects of Diet Soda on Gut Hormones in Youths With Diabetes.
56. Whole-Blood Tissue Factor Procoagulant Activity Is Elevated in Type 1 Diabetes and Effects of Hyperglycemia and Hyperinsulinemia.
57. Association of Basal hyperglucagonemia with impaired glucagon counterregulation in type 1 diabetes. Free full text available in HTML and PDF formats.
58. Autoantibodies and High-Risk HLA Susceptibility Markers in First-Degree Relatives of Brazilian Patients with Type 1 Diabetes Mellitus: A Progression to Disease Based Study.
59. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. See also Gut Cells Turned To Insulin Factories - New Type l Diabetes Treatment.

    7 March 2012

60. Closed-loop insulin delivery: towards improved diabetes care. Free full text available in HTML format.
61. The interplay of autoimmunity and insulin resistance in type 1 diabetes. Free full text available in HTML format.
62. Increasing Incidence and Age at Diagnosis among Children with Type 1 Diabetes Mellitus over a 20-Year Period in Auckland (New Zealand).
63. Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes; A Twin and Population Study.
64. Immunology in the clinic review series; focus on type 1 diabetes and viruses: the enterovirus link to type 1 diabetes: critical review of human studies.

    29 February 2012

65. Reversal of Diabetes Through Gene Therapy of Diabetic Rats by Hepatic Insulin Expression via Lentiviral Transduction.
66. The Accuracy Benefit of Multiple Amperometric Glucose Sensors in People With Type 1 Diabetes.
67. Preexisting Autoantibodies Predict Efficacy of Oral Insulin To Cure Autoimmune Diabetes in Combination With Anti-CD3.
68. Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of beta-cell Autoimmunity.
69. Historical data enhances safety supervision system performance in T1DM insulin therapy risk management.
70. Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism.
71. Arterial Stiffness Is Increased in Patients With Type 1 Diabetes Without Cardiovascular Disease; A potential role of low-grade inflammation.

    22 February 2012

72. Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay. See also Study finds some insulin production in long-term type 1 diabetes and Insulin production may persist for decades after onset of type 1 diabetes.
73. Does severe hypoglycaemia influence microvascular complications in Type 1 diabetes? An analysis of the Diabetes Control and Complications Trial database.

    15 February 2012

74. Genetics of type 1 diabetes. Free full text available in HTML and PDF formats.
75. Virus infections in type 1 diabetes. Free full text available in HTML and PDF formats.
76. CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. Free full text available in HTML and PDF formats.
77. Could the social environment trigger the induction of diabetes related autoantibodies in young children?
78. Infant and Toddler Type 1 Diabetes: Complications after 20 years’ duration.
79. Reversal of diabetes by beta-TC3 cells encapsulated in alginate beads generated by emulsion and internal gelation.
80. Hypoglycemia, but not Glucose Variability, Relates to Vascular Function in Children with Type 1 Diabetes.
81. Hyperfiltration in type 1 diabetes: does it exist and does it matter for nephropathy?
82. The branching pattern of villous capillaries and structural changes of placental terminal villi in type 1 diabetes mellitus.
83. Long-Term (5 Years) Efficacy and Safety of Pancreas Transplantation Alone in Type 1 Diabetic Patients.

8 February 2012

84. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus.
85. Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant.
86. Type 1 Diabetes Is Associated With Enterovirus Infection in Gut Mucosa.
87. Is the origin of type 1 diabetes in the gut?
88. Rising Incidence of Type 1 Diabetes Is Associated With Altered Immunophenotype at Diagnosis.
89. Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes.
90. Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk.
91. East Africans in Sweden Have a High Risk for Type 1 Diabetes.
92. Age-Related Loss of Brain Volume and T2 Relaxation Time in Youth With Type 1 Diabetes.

    1 February 2012

93. Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study). Free full text available in HTML and PDF formats.
94. Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: a randomized placebo-controlled crossover study.
95. Diabetic retinopathy in the SEARCH for Diabetes in Youth Cohort: a pilot study.
96. Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus.
97. Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring.
98. Proinsulin C-peptide interferes with insulin fibril formation.

    25 January 2012

99. Development of a fully automated closed loop artificial pancreas control system with dual pump delivery of insulin and glucagon.
100. Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years.
101. Advanced Glycation End Products as Environmental Risk Factors for the Development of Type 1 Diabetes.
102. A novel strategy for long-term implantable artificial pancreas.

     18 January 2012

103. Safe Glycemic Management during Closed-Loop Treatment of Type 1 Diabetes: The Role of Glucagon, Use of Multiple Sensors, and Compensation for Stress Hyperglycemia.
104. Closed-loop glucose control: psychological and behavioral considerations.
105. Continuous glucose monitoring considerations for the development of a closed-loop artificial pancreas system.
106. A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroid-induced stress hyperglycemia in type 1 diabetes.
107. Meta-analysis of overnight closed-loop randomized studies in children and adults with type 1 diabetes: the cambridge cohort.
108. Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study.
109. Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
110. Left ventricular filling patterns and its relation to left ventricular untwist in patients with type 1 diabetes and normal ejection fraction.
111. The Timing of Dialysis and Kidney Transplantation in Type 1 Diabetes.

     11 January 2012

112. Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells. Free full text available in PDF format. See also Novel Stem Cell Treatment May Hold Promise for Type 1 Diabetes and Type 1 Diabetes Reversed With Stem Cells From Cord Blood.
113. Characterization of a Novel Functional Protein in the Pancreatic Islet: Islet Homeostasis Protein Regulation of Glucagon Synthesis in alpha Cells. See also Researchers Discover Protein that May Represent New Target for Treating Type 1 Diabetes.
114. Promoting long-term survival of insulin-producing cell grafts that differentiate from adipose tissue-derived stem cells to cure type 1 diabetes. Free full text available in HTML and PDF formats.
115. 25-Hydroxyvitamin D Concentrations and In Vivo Insulin Sensitivity and beta-Cell Function Relative to Insulin Sensitivity in Black and White Youth.
116. The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes.
117. Blue Flash ERG PhNR Changes Associated with Poor Long-Term Glycemic Control in Adolescents with Type 1 Diabetes.

     4 January 2012

118. Towards an artificial pancreas at home.
119. Advances in pump technology: insulin patch pumps, combined pumps and glucose sensors, and implanted pumps.
120. Regulated and Reversible Induction of Adult Human beta-Cell Replication.
121. Latent Autoimmune Diabetes of Adults Is Phenotypically Similar to Type 1 Diabetes in a Minority Population.

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Last Updated: Wednesday May 23, 2012 14:42:24
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