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Research News From 2013

10 April 2013

1. Family psychological stress early in life and development of type 1 diabetes: The ABIS prospective study.
2. Enteroviral pathogenesis of type 1 diabetes: queries and answers.
3. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials.
4. Multivariable Adaptive Closed-Loop Control of an Artificial Pancreas Without Meal and Activity Announcement.
5. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
6. Alteration of the thymic T cell repertoire by rotavirus infection is associated with delayed type 1 diabetes development in non-obese diabetic mice. Free full text available in HTML and PDF formats.
7. Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice. Free full text available in HTML and PDF formats.

   3 April 2013

8. Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children.

   27 March 2013

9. Faster pharmacokinetics and increased patient acceptance of intradermal insulin delivery using a single hollow microneedle in children and adolescents with type 1 diabetes.
10. Circulating Vitamin D Metabolites and Subclinical Atherosclerosis in Type 1 Diabetes.
11. Positron emission tomography measured cerebral blood flow and glucose metabolism are decreased in human type 1 diabetes.
12. Protein intake in relation to risk of hypertension and microalbuminuria in patients with type 1 diabetes: the EURODIAB Prospective Complications Study.
13. Baseline Markers of Inflammation Are Associated With Progression to Macroalbuminuria in Type 1 Diabetic Subjects.
14. Factors associated with the presence of glutamic acid decarboxylase and islet antigen-2 autoantibodies in patients with long-standing type 1 diabetes.
15. Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with increased Exocrine Pancreas Dysplasia and the potential for Glucagon-producing Neuroendocrine Tumors.

    20 March 2013

16. Population-based Survey of the Prevalence of Type 1 and Type 2 diabetes in School Children in Philadelphia.
17. Addition of exenatide or sitagliptin to insulin in new onset type 1 diabetes: A randomized, open label study.
18. Association of the incidence of type 1 diabetes with markers of infection and antibiotic susceptibility at country level. See also Global Rise in Type 1 Diabetes May Be Linked to Reduced Exposure to Pathogens in Early Life.
19. Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes.
20. Induced autologous stem cell transplantation for treatment of rabbit type 1 diabetes.
21. Long-term bisphenol A exposure accelerates insulitis development in diabetes-prone NOD mice.

    13 March 2013

22. Can C-peptide mediated anti-inflammatory effects retard the development of microvascular complications of type 1 diabetes?
23. In type 1 diabetes a subset of anti-coxsackievirus b4 antibodies recognize autoantigens and induce apoptosis of pancreatic Beta cells. Free full text available in HTML and PDF formats (link on HTML full text page).
24. Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel.
25. The Association between IgG4 Antibodies to Dietary Factors, Islet Autoimmunity and Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young. Free full text available in HTML and PDF formats (link on HTML full text page).
26. Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.

    6 March 2013

27. Nocturnal Glucose Control with an Artificial Pancreas at a Diabetes Camp. See also Artificial Pancreas Worked Overnight on Kids With Type 1 Diabetes.
28. Overnight automated type 1 diabetes control under MD-logic closed-loop system: a randomized crossover trial.
29. Does farm environment protect against type 1 diabetes mellitus? Free full text available in HTML and PDF formats.
30. Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes. See also First single gene mutation shown to result in type 1 diabetes and First Single Gene Mutation Shown to Result in Type 1 Diabetes.
31. Treatment of diabetes mellitus with microencapsulated fetal human liver (FH-B-TPN) engineered cells.
32. The Relationship of Sugar to Population-Level Diabetes Prevalence: An Econometric Analysis of Repeated Cross-Sectional Data explores the impact of exposure to sugar on the risk of type 2 diabetes -- still quite relevant to anyone with type 1 diabetes. See also Study: Sugar — Not Obesity — Causes Diabetes and Sugar In Diet Linked To Type 2 Diabetes Rates, Study Finds.
33. The Diabetes Research Institute announced the DRI BioHub, an artificial organ platform designed to protect islets and provide euglycemia without whole-body immunosuppression, as is required by traditional islet transplants. This announcement of this effort generated heated discussion throughout the online community, not all of it positive. For more, see the following:
    
    
    1. This Could Be It.... What We Have Been Waiting For Since Diagnosis!!!!
    2. A Message from Diabetes Dad.
    3. Could it be....
    4. New DRI Mini ‘BioHub’ Organ Would Mimic a Healthy Pancreas.
    5. Hope without hype is all we ask (the one when I wish it started differently).
    6. Don’t Believe the Hype.
    7. News from the DRI.
    8. Our Community.
    9. My Take on the Hub-bub About the Bio Hub.
    10. Empathy. Honoring struggle without trite solutions.
    11. Meanwhile, In Other News....

    27 February 2013

34. Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study. Free full text available in PDF format.
35. Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease.
36. Immune Therapy and beta-Cell Death in Type 1 Diabetes.
37. Reactivation of latent viruses in individuals receiving rituximab for new onset type 1 diabetes.
38. Proinsulin/Insulin Autoantibodies Measured With Electrochemiluminescent Assay Are the Earliest Indicator of Prediabetic Islet Autoimmunity .
39. More people needed for type 1 diabetes vaccine study.

    20 February 2013

40. Allogeneic Bone Marrow Cocultured With Human Islets Significantly Improves Islet Survival and Function In Vivo.
41. Human milk can neutralize Coxsackievirus B4 in vitro.
42. Promotion of Autoimmune Diabetes by Cereal Diet in the Presence or Absence of Microbes Associated With Gut Immune Activation, Regulatory Imbalance, and Altered Cathelicidin Antimicrobial Peptide.

    13 February 2013

43. Treatment of Diabetes and Long-term Survival Following Insulin and Glucokinase Gene Therapy. See also UAB researchers cure type 1 diabetes in dogs, Type 1 Diabetes Cured In Dogs, and Type 1 Diabetes Cured in Dogs, Study Suggests.
44. Differences in glucose-stimulated insulin secretion in vitro of islets from human, nonhuman primate, and porcine origin.
45. Efficacy and Safety of Insulin Degludec in a Flexible Dosing Regimen vs Insulin Glargine in Patients With Type 1 Diabetes (BEGIN: Flex T1): A 26-Week Randomized, Treat-to-Target Trial With a 26-Week Extension.
46. Evidence of Association between Type 1 Diabetes and Exposure to Enterovirus in Cuban Children and Adolescents. Free full text available in PDF format.
47. A randomized placebo-controlled trial of alphacalcidol on the preservation of beta cell function in children with recent onset type 1 diabetes.

    6 February 2013

48. Glucose-responsive insulin and glucagon delivery (dual-hormone artificial pancreas) in adults with type 1 diabetes: a randomized crossover controlled trial. Free full text available in PDF format.
49. Preclinical Serum 25-Hydroxyvitamin D Levels and Risk of Type 1 Diabetes in a Cohort of US Military Personnel. See also ‘Sunshine vitamin’ looks a little brighter.
50. HLA Class I and II Alleles are Associated with Microvascular Complications of Type 1 Diabetes.
51. PDX1-engineered embryonic stem cell-derived insulin producing cells regulate hyperglycemia in diabetic mice. Free full text available in HTML and PDF formats.

    30 January 2013

52. Glucose-responsive insulin and glucagon delivery (dual-hormone artificial pancreas) in adults with type 1 diabetes: a randomized crossover controlled trial. Free full text available in PDF format. See also Artificial pancreas: the way of the future for treating type 1 diabetes.
53. Promotion of autoimmune diabetes by cereal diet in the presence or absence of microbes associated with gut immune activation, regulatory imbalance and altered cathelicidin antimicrobial peptide .
54. Verification of Skin Autofluorescence Values by Mass Spectrometry in Adolescents with Type 1 Diabetes: Brief Report.
55. Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice.

    23 January 2013

56. Increasing Incidence of Type 1 Diabetes in Youth - Twenty years of the Philadelphia Pediatric Diabetes Registry. See also Type 1 Diabetes in Urban Children Skyrockets.
57. Prophylactic and Antinociceptive Effects of Coenzyme Q10 on Diabetic Neuropathic Pain in a Mouse Model of Type 1 Diabetes.
58. Endothelial Progenitor Cells Are Related to Glycemic Control in Children With Type 1 Diabetes Mellitus Over Time.
59. Macro- or microencapsulation of pig islets to cure type 1 diabetes. Free full text available in HTML and PDF formats.
60. The Hygiene Theory Harnessing Helminths and Their Ova to Treat Autoimmunity.
61. Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity. See also Transplanted Gut Bugs Protect Mice from Diabetes and Good Bacteria in the Intestine Prevent Diabetes, Study Suggests.

    16 January 2013

62. The role of the intestinal microbiota in type 1 diabetes.
63. Reduction of Number and Duration of Hypoglycemic Events by Glucose Prediction Methods: A Proof-of-Concept In Silico Study.
64. Hypoglycemia-related electroencephalogram changes are independent of gender, age, duration of diabetes, and awareness status in type 1 diabetes.
65. Use of an intravascular fluorescent continuous glucose sensor in subjects with type 1 diabetes mellitus.
66. Neurovascular dysfunction precedes neural dysfunction in the retina of patients with type 1 diabetess.
67. Cross-Sectional Evaluation of Noninvasively Detected Skin Intrinsic Fluorescence and Mean Hemoglobin A1c in Type 1 Diabetes.
68. Comparison of annual variability in HbA1c and glycated albumin in patients with type 1 vs. type 2 diabetes mellitus.
69. Patients with type 1 diabetes exhibit altered cerebral metabolism during hypoglycemia.

    9 January 2013

70. Helminth mediated modulation of Type 1 diabetes (T1D).
71. C-peptide in diabetes diagnosis and therapy.
72. Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus.
73. Long term reversal of diabetes in non obese diabetic mice by liver-directed gene therapy.
74. Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study.

    2 January 2013

75. Fecal Microbiota Composition Differs Between Children With beta-Cell Autoimmunity and Those Without. See also Could prebiotics or probiotics cure type 1 diabetes?
76. The Effects of n-3 Long-Chain Polyunsaturated Fatty Acid Supplementation on Biomarkers of Kidney Injury in Adults With Diabetes.
77. The age of onset of diabetes and glutamic acid decarboxylase titer measured long after diagnosis are associated with the clinical stage of slow-onset type 1 diabetes.

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Last Updated: Wednesday April 10, 2013 16:13:39
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