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Research News From 2016

    28 December 2016

  1. Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial. See also Bionic pancreas system manages blood sugar levels in patients with type 1 diabetes living at home.
  2. Aggregation of Engineered Human β-Cells Into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu. Free full text available in HTML and PDF formats.
  3. Vitamin D on Early Stages of Diabetic Kidney Disease: A Cross-sectional Study in Patients with Type 1 Diabetes Mellitus.

    21 December 2016

  4. Feasibility of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery.
  5. MD-Logic Overnight Type 1 Diabetes Control in Home Settings: Multicenter, Multinational, Single blind, Randomized Trial.
  6. Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years.
  7. Similar pharmacokinetics and pharmacodynamics of rapid-acting insulin lispro products SAR342434 and US- and EU-approved Humalog® in subjects with type 1 diabetes.
  8. Evaluation of the Counter-regulatory Responses to Hypoglycemia in Patients with Type 1 Diabetes during Opiate Receptor Blockade with Naltrexone.

    14 December 2016

  9. β-cell–mimetic designer cells provide closed-loop glycemic control.
  10. Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes. Free full text available in HTML and PDF formats.
  11. Metformin in adults with type 1 diabetes: design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): an international multicentre trial.

    7 December 2016

  12. Assessing the population impact of low rates of vitamin D supplementation on type 1 diabetes using a new statistical method. Free full text available in HTML and PDF formats.
  13. Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity. Free full text available in PDF format. See also Breakthrough in diabetes research: Pancreatic cells produce insulin instead of glucagon upon artemisinin treatment and Anti-malaria drugs could be linked to type 1 diabetes treatment.
  14. Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells. Free full text available in HTML and PDF formats. See also CRISPR editing in pancreatic cells reduced cell death, increased insulin secretion.
  15. Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. Free full text available in HTML and PDF formats.
  16. Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry.

    30 November 2016

  17. Pharmacokinetic and Pharmacodynamic Properties of Faster-Acting Insulin Aspart versus Insulin Aspart Across a Clinically Relevant Dose Range in Subjects with Type 1 Diabetes Mellitus.
  18. A Comparison of Pharmacokinetic and Pharmacodynamic Properties Between Faster-Acting Insulin Aspart and Insulin Aspart in Elderly Subjects with Type 1 Diabetes Mellitus.
  19. A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis.
  20. Oxygenation of the Intraportally Transplanted Pancreatic Islet. Free full text available in HTML and PDF formats.

    23 November 2016

  21. Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.
  22. Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus.
  23. A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials.

    16 November 2016

  24. A Novel Insulin/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump Therapy. Free full text available in HTML and PDF formats.
  25. Sensor Life and Overnight Closed Loop: A Randomized Clinical Trial.
  26. Associations between long chain polyunsaturated fatty acids and cardiovascular lipid risk factors in youth with type 1 diabetes: SEARCH Nutrition Ancillary Study.
  27. Islet cell transplantation improves nerve conduction velocity in type 1 diabetes compared with intensive medical therapy over six years.
  28. Optimizing Porcine Islet Isolation to Markedly Reduce Enzyme Consumption Without Sacrificing Islet Yield or Function. Free full text available in HTML and PDF formats.

    9 November 2016

  29. Accuracy and Longevity of an Implantable Continuous Glucose Sensor in the PRECISE Study: A 180-Day, Prospective, Multicenter, Pivotal Trial.
  30. Efficacy of an Overnight Predictive Low-Glucose Suspend System in Relation to Hypoglycemia Risk Factors in Youth and Adults With Type 1 Diabetes.
  31. A Review of Safety and Design Requirements of the Artificial Pancreas. Free full text available in HTML and PDF formats.
  32. Early Detection of Infusion Set Failure During Insulin Pump Therapy in Type 1 Diabetes.
  33. Long-Term Improvement in Glucose Control and Counterregulation by Islet Transplantation for Type 1 Diabetes.
  34. Increased Proliferation of the Pancreatic Duct Gland Compartment in Type 1 Diabetes. Free full text available in PDF format.
  35. The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study.
  36. Peptide serum markers in islet autoantibody-positive children. See also Proteins as an early warning system for type 1 diabetes?
  37. No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study.
  38. Vitamin D-binding protein and 25-hydroxyvitamin D during pregnancy in mothers whose children later developed type 1 diabetes.
  39. Low vitamin D level in pediatric patients with new onset type 1 diabetes is common, especially if in ketoacidosis.
  40. Incidence, prevalence, costs and quality of care of type 1 diabetes in Italy, age 0-29 years: The population-based CINECA-SID ARNO Observatory, 2002-2012.

    2 November 2016

  41. Risk of future microvascular and macrovascular disease in people with Type 1 diabetes of very long duration: a national study with 10-year follow-up.
  42. Cardiovascular Autonomic Neuropathy and Cardiovascular Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.
  43. Albuminuria Changes and Cardiovascular and Renal Outcomes in Type 1 Diabetes: The DCCT/EDIC Study.
  44. Immunogenicity of human embryonic stem cell-derived beta cells.
  45. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. See also UMMS researchers isolate immune cells from the islets of donors with type 1 diabetes.
  46. Insulitis in human diabetes: a histological evaluation of donor pancreases.
  47. Clinical Benefit of Islet Xenotransplantation for the Treatment of Type 1 Diabetes. Free full text available in HTML and PDF formats.
  48. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice.

    25 October 2016

  49. Using uncertain data from body-worn sensors to gain insight into type 1 diabetes. Free full text available in HTML and PDF formats.
  50. Pharmacokinetic Properties of Liraglutide as Adjunct to Insulin in Subjects with Type 1 Diabetes Mellitus.
  51. Higher skin autofluorescence in young people with Type 1 diabetes and microvascular complications.
  52. Phototherapy and Risk of Type 1 Diabetes.

    19 October 2016

  53. Heart rate informed artificial pancreas system enhances glycemic control during exercise in adolescents with T1D.
  54. A description of clinician reported diagnosis of type 2 diabetes and other non-type 1 diabetes included in a large international multicentered pediatric diabetes registry (SWEET).
  55. Stimulated urine C-peptide creatinine ratio vs serum C-peptide level for monitoring of β-cell function in the first year after diagnosis of Type 1 diabetes.

    12 October 2016

  56. Efficacy of single-hormone and dual-hormone artificial pancreas during continuous and interval exercise in adult patients with type 1 diabetes: randomised controlled crossover trial.
  57. Basal insulin peglispro: Overview of a novel long-acting insulin with reduced peripheral effect resulting in a hepato-preferential action.
  58. Pharmacological properties of faster-acting insulin aspart versus insulin aspart in patients with type 1 diabetes using continuous subcutaneous insulin infusion: a randomised, double-blind, crossover trial.
  59. Reduced peripheral activity leading to hepato-preferential action of basal insulin peglispro compared with insulin glargine in patients with type 1 diabetes.
  60. Different effects of basal insulin peglispro and insulin glargine on liver enzymes and liver fat content in patients with type 1 and type 2 diabetes.
  61. GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis.
  62. Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. See also New approach to treating type 1 diabetes aims to limit damage caused by our own immune system.
  63. A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes. Free full text available in HTML and PDF formats.

    5 October 2016

  64. Evaluating the Experience of Children With Type 1 Diabetes and Their Parents Taking Part in an Artificial Pancreas Clinical Trial Over Multiple Days in a Diabetes Camp Setting.
  65. Psychological outcomes of evening and night closed-loop insulin delivery under free living conditions in people with Type 1 diabetes: a 2-month randomized crossover trial.
  66. Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study. Free full text available in HTML and PDF formats.
  67. Compensatory Hyper-Connectivity in Developing Brains of Young Children with Type 1 Diabetes.
  68. Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes.
  69. MicroRNA-126 and micro-/macrovascular complications of type 1 diabetes in the EURODIAB Prospective Complications Study.
  70. Neurocognitive consequences of diabetes.

    28 September 2016

  71. Use of antibiotics in childhood and risk of Type 1 diabetes: a population-based case-control study.
  72. Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose. Free full text available in HTML and PDF formats.
  73. Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease: A Systematic Review and Meta-analysis.
  74. Glycemic variability predicts inflammation in adolescents with type 1 diabetes.
  75. Is the incidence of type 1 diabetes in children and adolescents stabilising? The first 6 years of a National Register.
  76. Glycemic Control Indices and Their Aggregation in the Prediction of Nocturnal Hypoglycemia From Intermittent Blood Glucose Measurements.
  77. Anti-Thymocyte Globulin + G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders with Established Type 1 Diabetes.
  78. The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus.
  79. Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival. Free full text available in HTML and PDF formats.

    21 September 2016

  80. Safety of a Hybrid Closed-Loop Insulin Delivery System in Patients With Type 1 Diabetes. PDF available with free JAMA account login.
  81. Early Detection of Infusion Set Failure During Insulin Pump Therapy in Type 1 Diabetes.
  82. Modelling Day-to-Day Variability of Glucose-Insulin Regulation over 12-Week Home Use of Closed-Loop Insulin Delivery. Free full text available in PDF format.
  83. Dipeptidyl peptidase-4 activity is associated with urine albumin excretion in type 1 diabetes.
  84. Type 1 diabetes in Sardinia: facts and hypotheses in the context of worldwide epidemiological data.
  85. Thinking outside the insulin box: McMaster researchers link improved muscle health to better outcomes for people with diabetes. See also Myostatin inhibition therapy for insulin-deficient type 1 diabetes and Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Mellitus is the Result of Altered Notch Signaling.

    14 September 2016

  86. Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Suboptimally Controlled Adolescents With Type 1 Diabetes: A 3-Week, Free-Living, Randomized Crossover Trial.
  87. A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin. See also Snails' speedy insulin: Bio-inspired insulin may act three times faster than current products and Snail venom holds key to better diabetes treatments.
  88. Increased skin autofluorescence of children and adolescents with type 1 diabetes despite a well-controlled HbA1c: results from a cohort study. Free full text available in HTML and PDF formats.
  89. Skin Autofluorescence is Associated with Early-stage Atherosclerosis in Patients with Type 1 Diabetes.
  90. Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin.
  91. Coincidence of PTPN22 c.1858CC and FCRL3 -169CC genotypes as a biomarker of preserved residual β-cell function in children with type 1 diabetes.
  92. Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes.
  93. Development of Insulin Detemir/Insulin Aspart Cross-Reacting Antibodies Following Treatment with Insulin Detemir: 104-week Study in Children and Adolescents with Type 1 Diabetes Aged 2-16 Years.
  94. Clinical Benefit of Islet Xenotransplantation for the Treatment of Type 1 Diabetes. Free full text available in HTML and PDF formats.

    7 September 2016

  95. Skin autofluorescence predicts cardio-renal outcome in type 1 diabetes: a longitudinal study. Free full text available in HTML and PDF formats.

    31 August 2016

  96. Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study. Free full text available in HTML and PDF formats.
  97. Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes.
  98. Long-term improvement in glucose control and counterregulation by islet transplantation for type 1 diabetes.

    24 August 2016

  99. Closed-Loop Insulin Delivery during Pregnancy in Women with Type 1 Diabetes. Free full text available in HTML and PDF formats.
  100. β-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells. Free full text available in HTML and PDF formats.
  101. Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure. Free full text available in HTML and PDF formats.
  102. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. See also Antibiotic Therapy During Infancy Increases Type 1 Diabetes Risk in Mice.
  103. The prevalence of small intestinal bacterial overgrowth (SIBO) in adult patients with type 1 diabetes and relationship with metabolic control and the presence of chronic complications of the disease. Free full text available in PDF format.
  104. Association between type 1, type 2 cytokines, diabetic autoantibodies and 25-hydroxyvitamin D in children with type 1 diabetes.
  105. Mixed success for Victoza in type 1 diabetes trials.

    17 August 2016

  106. Effectiveness of a Predictive Algorithm in the Prevention of Exercise-Induced Hypoglycemia in Type 1 Diabetes.
  107. Effect of autoimmunity risk loci on the honeymoon phase in type 1 diabetes.

    10 August 2016

  108. Islet transplantation provides superior glycemic control with less hypoglycemia compared to continuous subcutaneous insulin infusion (CSII) or multiple daily insulin injections (MDI).
  109. Well, I Wouldn't be Any Worse Off, Would I, Than I am Now? A Qualitative Study of Decision-Making, Hopes, and Realities of Adults With Type 1 Diabetes Undergoing Islet Cell Transplantation.
  110. Duration of Action of Two Insulin Glargine Products, LY2963016 Insulin Glargine and Lantus® Insulin Glargine, in Subjects with Type 1 Diabetes Mellitus.
  111. Lipid Changes During Basal Insulin Peglispro, Insulin Glargine, or NPH Treatment in 6 IMAGINE Trials.
  112. Is there a role for gut microbiota in type 1 diabetes pathogenesis?

    3 August 2016

  113. New Devices Will 'Revolutionize' T1 Diabetes Care.
  114. Hypoglycemia Detection and Carbohydrate Suggestion in an Artificial Pancreas.
  115. Combination high-dose omega-3 fatty acids and high-dose cholecalciferol in new onset type 1 diabetes: a potential role in preservation of beta-cell mass. Free full text available in PDF format.
  116. Antigen-based immunotherapies do not prevent progression of recent-onset autoimmune diabetes: a systematic review and meta-analysis.
  117. Cardiac Assessment of Patients With Type 1 Diabetes Median 10 Years After Successful Simultaneous Pancreas and Kidney Transplantation Compared With Living Donor Kidney Transplantation.

    27 July 2016

  118. Coprogression of Cardiovascular Risk Factors in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study.

    20 July 2016

  119. Factors contributing to partial remission in type 1 diabetes: analysis based on the insulin dose-adjusted HbA1c in 3657 children and adolescents from Germany and Austria.
  120. Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA1c, and Insulin Dose.
  121. Dysregulation of glucose metabolism in preclinical type 1 diabetes. Free full text also available in PDF format.
  122. A novel approach for the analysis of longitudinal profiles reveals delayed progression to type 1 diabetes in a subgroup of multiple-islet-autoantibody-positive children.

    13 July 2016

  123. How Much Is Short-Term Glucose Prediction in Type 1 Diabetes Improved by Adding Insulin Delivery and Meal Content Information to CGM Data? A Proof-of-Concept Study.
  124. Cerebral blood flow response to hypoglycemia is altered in patients with type 1 diabetes and impaired awareness of hypoglycemia.
  125. High-dose atorvastatin is associated with lower IGF-1 levels in patients with type 1 diabetes.
  126. Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes: a pilot study.
  127. The evolving role of bariatric surgery in patients with type 1 diabetes and obesity.

    29 June 2016

  128. Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report. Free full text available in PDF format.
  129. Randomized trial of a dual-hormone artificial pancreas with dosing adjustment during exercise compared with no adjustment and sensor-augmented pump therapy.
  130. Comparative Pharmacokinetic/Pharmacodynamic Study of Liquid Stable Glucagon Versus Lyophilized Glucagon in Type 1 Diabetes Subjects.
  131. The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2).
  132. Recruitment Into a Pediatric Continuous Glucose Monitoring RCT: Patient and Recruitment Process Characteristics Associated With Decision to Participate.
  133. Altered Integration of Structural Covariance Networks in Young Children With Type 1 Diabetes.

    22 June 2016

  134. Automated glucagon delivery reduces hypoglycemia in type 1 diabetes.
  135. Autonomic nervous system function assessed by conventional and spectral analysis might be useful in terms of predicting retinal deterioration in persons with type 1 diabetes mellitus.

    15 June 2016

  136. Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes.
  137. Systematic Review: Early Infant Feeding and the Risk of Type 1 Diabetes.
  138. Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas.
  139. Effects of intraperitoneal insulin versus subcutaneous insulin administration on sex hormone-binding globulin concentrations in patients with type 1 diabetes mellitus. Free full text available in HTML and PDF formats.

    8 June 2016

  140. Day-and-Night Closed-Loop Control Using the Unified Safety System in Adolescents With Type 1 Diabetes at Camp.
  141. Generation of Functional Beta-Like Cells from Human Exocrine Pancreas. Free full text available in HTML and PDF formats.
  142. Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies.
  143. Predictors of slow progression to diabetes in children with multiple islet autoantibodies.
  144. Pancreas-protective effect of rituximab for acute-onset type 1 diabetes in the honeymoon period: a case report. Free full text available in HTML and PDF formats.
  145. Experimental Therapy Shows Promise for Type 1 Diabetes.
  146. Current outcomes in islet versus solid organ pancreas transplant for β-cell replacement in type 1 diabetes.
  147. Retention of gene expression in porcine islets after agarose encapsulation and long-term culture.

    1 June 2016

  148. Enhanced differentiation of human amniotic fluid-derived stem cells into insulin-producing cells in vitro.
  149. Frequency of Diabetes and Thyroid Autoantibodies in Patients with Type 1 Diabetes and Their Siblings. Free full text available in HTML and PDF formats.
  150. Non-invasive, home-based electroencephalography hypoglycaemia warning system for personal monitoring using skin surface electrodes: a single-case feasibility study.

    25 May 2016

  151. Efficacy of an Overnight Predictive Low-Glucose Suspend System in Relation to Hypoglycemia Risk Factors in Youth and Adults With Type 1 Diabetes.
  152. Automated Overnight Closed-Loop Control Using a Proportional-Integral-Derivative Algorithm with Insulin Feedback in Children and Adolescents with Type 1 Diabetes at Diabetes Camp.
  153. Automated hybrid closed-loop control with a proportional-integral-derivative based system in adolescents and adults with type 1 diabetes: individualizing settings for optimal performance.
  154. A Simplified Semi-quantitative Meal Bolus Strategy Combined with Single- and Dual-hormone Closed-loop Delivery in Patients with Type 1 Diabetes: A Pilot Study.
  155. Adjuvant Liraglutide and Insulin Versus Insulin Monotherapy in the Closed-Loop System in Type 1 Diabetes: A Randomized Open-Labeled Crossover Design Trial.
  156. Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial.
  157. Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study. Free full text available in HTML and PDF formats.
  158. Progress and challenges for treating Type 1 diabetes.
  159. Partners for life.

    18 May 2016

  160. Carbohydrate Estimation by a Mobile Phone-Based System Versus Self-Estimations of Individuals With Type 1 Diabetes Mellitus: A Comparative Study. Free full text available in HTML format.
  161. Human type 1 diabetes is characterized by an early, marked, sustained and islet-selective loss of sympathetic nerves.
  162. Day and Night Closed-Loop Glucose Control in Patients With Type 1 Diabetes Under Free-Living Conditions: Results of a Single-Arm 1-Month Experience Compared With a Previously Reported Feasibility Study of Evening and Night at Home.
  163. Mitigating Meal-Related Glycemic Excursions in an Insulin-Sparing Manner During Closed-Loop Insulin Delivery: The Beneficial Effects of Adjunctive Pramlintide and Liraglutide.
  164. Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe.
  165. Insulin Gene Therapy for Type 1 Diabetes Mellitus: Unique Challenges Require Innovative Solutions.
  166. Glucodynamics of Long-Acting Basal Insulin Peglispro (BIL) Compared With Insulin Glargine at Steady State in Subjects with Type 1 Diabetes: substudy of a randomized crossover trial.

    11 May 2016

  167. Prevention of Insulin-Induced Hypoglycemia in Type 1 Diabetes with Predictive Low Glucose Management System.
  168. Efficacy and safety of otelixizumab use in new-onset type 1 diabetes mellitus.
  169. Type 1 diabetes prevalence increasing globally and regionally: the role of natural selection and life expectancy at birth. Free full text available in HTML and PDF formats. See also Advances in medical care have led to type 1 diabetes boom.
  170. Generation of stem cell-derived β-cells from patients with type 1 diabetes. See also Stem cells from diabetic patients coaxed to become insulin-secreting cells.
  171. Higher diversity in fungal species discriminates children with type 1 diabetes mellitus from healthy control. Free full text available in HTML and PDF formats.

    4 May 2016

  172. In-home nighttime predictive low glucose suspend experience in children and adults with type 1 diabetes.
  173. Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production. Free full text available in HTML and PDF formats.
  174. B Cell-targeted Immunotherapy for Type 1 Diabetes: What Can Make It Work?
  175. Infections in Early Life and Development of Type 1 Diabetes. See also Recurrent viral respiratory tract infections during first 6 months and risk of T1 diabetes and Infections can increase risk for type 1 diabetes in children.
  176. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study.
  177. Replicative capacity of β-cells and type 1 diabetes.
  178. A difficult case of recurrent hypoglycaemia: role of insulin assays in establishing the diagnosis.

    27 April 2016

  179. Multinational Home Use of Closed-Loop Control Is Safe and Effective.
  180. Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study.
  181. Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.
  182. Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes. See also Final piece of type 1 diabetes puzzle solved and Scientists Have Solved A Major Diabetes Mystery.
  183. Vitamin D-binding protein and 25-hydroxyvitamin D during pregnancy in mothers whose children later developed type 1 diabetes.
  184. Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.
  185. Incidence of Type 1 Diabetes among Children and Adolescents in Italy between 2009 and 2013: The Role of a Regional Childhood Diabetes Registry. Free full text available in HTML and PDF formats.

    20 April 2016

  186. Primary prevention of beta-cell autoimmunity and type 1 diabetes - The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives. Free full text available in HTML and PDF formats.
  187. Invokana increases rates of ketone-related adverse events in type 1 diabetes.
  188. Victoza Study in T1D Yields Inconsistent Results.

    13 April 2016

  189. Recent trends in life expectancy for people with type 1 diabetes in Sweden.
  190. Type 1 Diabetes Life Expectancy Still 12 Years Short of Norm. (Free Medscape membership required)
  191. Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells. Free full text available in HTML and PDF formats.
  192. Cost effectiveness and value of information analyses of islet cell transplantation in the management of 'unstable' type 1 diabetes mellitus.

    6 April 2016

  193. Prelabor Cesarean Section and Risk of Childhood Type 1 Diabetes - A Nationwide Register-Based Cohort Study.
  194. HLA-DRB1*03 as a risk factor for microalbuminuria in same duration of type 1 diabetes: a case control study. Free full text available in HTML and PDF formats.
  195. Validation of a Rapid Type 1 Diabetes Autoantibody Screening Assay for Community Based Screening of Organ Donors to Identify Subjects at Increased Risk for the Disease.
  196. Increased mortality in a Danish cohort of young people with Type 1 diabetes mellitus followed for 24 years. See also New studies reveal large gap in life expectancy between patients with type 1 diabetes and the general population.
  197. Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults (LADA).
  198. ENDO: Farxiga Proves Effective in T1D, But Is it Safe?
  199. Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.
  200. Vitamin D and pancreas: the role of sunshine vitamin in the pathogenesis of Diabetes Mellitus and Pancreatic Cancer.
  201. Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes. Free full text available in HTML and PDF formats.

    30 March 2016

  202. Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood: The Environmental Determinants of Diabetes in the Young Study.
  203. Commonly Measured Clinical Variables Are Not Associated With Burden of Complications in Long-standing Type 1 Diabetes: Results From the Canadian Study of Longevity in Diabetes.
  204. Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport. Free full text available in HTML and PDF formats.
  205. Life and death of β cells in Type 1 diabetes: A comprehensive review.
  206. Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes.
  207. Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

    23 March 2016

  208. Performance and safety of an integrated bihormonal artificial pancreas for fully automated glucose control at home.
  209. GoCARB in the Context of an Artificial Pancreas.
  210. Artificial Pancreas Success in Type 1 Diabetes in Pregnancy.
  211. The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants.
  212. Type 1 diabetes prevalence increasing globally and regionally: the role of natural selection and life expectancy at birth. Free full text available in HTML and PDF formats.
  213. The incidence rate and prevalence of pediatric type 1 diabetes mellitus (age 0-18) in the Italian region Friuli Venezia Giulia: population-based estimates through the analysis of health administrative databases.
  214. Lipoprotein composition in patients with type 1 diabetes mellitus: Impact of lipases and adipokines.
  215. Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease.
  216. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration.

    16 March 2016

  217. Is Psychological Stress a Factor for Incorporation Into Future Closed-Loop Systems?
  218. Variability of Insulin Requirements Over 12 Weeks of Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes.
  219. Aspects of Hyperglycemia Contribution to Arterial Stiffness and Cardiovascular Complications in Patients With Type 1 Diabetes.

    9 March 2016

  220. Early Formation of Serum Advanced Glycation End-Products in Children with Type 1 Diabetes Mellitus: Relationship with Glycemic Control.
  221. Estimated insulin sensitivity predicts incident micro- and macrovascular complications in adults with type 1 diabetes over 6 years: the coronary artery calcification in type 1 diabetes study.
  222. Early Corneal Cellular and Nerve Fiber Pathology in Young Patients With Type 1 Diabetes Mellitus Identified Using Corneal Confocal Microscopy. Free full text available in HTML and PDF via link on full text HTML page.
  223. Real-Time Model-Based Fault Detection of Continuous Glucose Sensor Measurements.

    2 March 2016

  224. The Pharmacodynamics, Safety, and Pharmacokinetics of Single Doses of the Motilin Agonist, Camicinal, in Type 1 Diabetes Mellitus with Slow Gastric Emptying.
  225. Hypoglycemia-Associated EEG Changes in Prepubertal Children With Type 1 Diabetes.
  226. Epidemiology of Type 1 Diabetes Mellitus in Korea through an Investigation of the National Registration Project of Type 1 Diabetes for the Reimbursement of Glucometer Strips with Additional Analyses Using Claims Data. Free full text available in HTML and PDF formats.
  227. Immune recognition and response to the intestinal microbiome in type 1 diabetes.
  228. The state of the art of islet transplantation and cell therapy in type 1 diabetes.
  229. Recent advances in understanding Type 1 Diabetes. Free full text available in HTML and PDF formats.

    24 February 2016

  230. AP@home: The Artificial Pancreas Is Now at Home.
  231. Hybrid Closed-Loop Insulin Delivery in Type 1 Diabetes During Supervised Outpatient Conditions.
  232. Effects of Frequency of Sensor-Augmented Pump Use on HbA1c.
  233. Association between intestinal permeability and fecal microbiota composition in Italian children with beta cell autoimmunity at risk for type 1 diabetes.
  234. Associations of growth patterns and islet autoimmunity in children with increased risk for type 1 diabetes: a functional analysis approach.
  235. Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes.
  236. Endocrine autoimmunity in patients with Latent Autoimmune Diabetes in Adults (LADA) - association with HLA genotype.

    17 February 2016

  237. Long-Term Insulin Independence in Type 1 Diabetes Mellitus Using a Simplified Autologous Stem Cell Transplant.
  238. Glucagon Nasal Powder: A Promising Alternative to Intramuscular Glucagon in Youth With Type 1 Diabetes.
  239. Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial.
  240. Variation in SLC19A3 and Protection from Microvascular Damage in Type 1 Diabetes. See also Researchers discover a genetic mutation that prevents diabetes complications.

    10 February 2016

  241. Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial.
  242. Feasibility of an Orthogonal Redundant Sensor incorporating Optical plus Redundant Electrochemical Glucose Sensing.
  243. Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT/EDIC Study 30-Year Follow-up. Free full text available in PDF format.
  244. Differential insulitic profiles determine the extent of beta cell destruction and the age at onset of type 1 diabetes. Free full text available in PDF format. See also Type 1 diabetics have 'sleeping' insulin cells which could be woken, say scientists and Childhood diabetes discoveries could lead to new treatments.
  245. Islet-after-failed-pancreas and pancreas-after-failed islet transplantation: two complementary rescue strategies to control diabetes.
  246. The Advanced Technologies & Treatments for Diabetes 2015 Yearbook is now available online.
  247. Nonaqueous, Mini-Dose Glucagon for Treatment of Mild Hypoglycemia in Adults With Type 1 Diabetes: A Dose-Seeking Study.
  248. Risk Factors Associated With Corneal Nerve Alteration in Type 1 Diabetes in the Absence of Neuropathy: A Longitudinal In Vivo Corneal Confocal Microscopy Study.
  249. Predominance of DR3 in Somali children with type 1 diabetes in the twin cities, Minnesota.
  250. Diabetes Diagnosis of the Future: 11 Types?

    3 February 2016

  251. First report on the nationwide incidence and prevalence of Type 1 diabetes among children in Turkey.
  252. Beta-cell mass in non-diabetic autoantibody-positive subjects: an analysis based on the nPOD database.
  253. Significant elevation of serum dipeptidyl peptidase-4 activity in young-adult type 1 diabetes.
  254. Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies. Free full text available in HTML and PDF formats.
  255. Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes. Free full text available in HTML and PDF formats.
  256. Resting beta-cells - A functional reserve?
  257. High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy. Free full text available in HTML and PDF formats.

    27 January 2016

  258. Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice. See also Potential diabetes treatment advances and No more insulin injections?
  259. The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes.
  260. Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus. Free full text available in HTML and PDF formats.
  261. Life expectancy of type 1 diabetic patients during 1997-2010: a national Australian registry-based cohort study.
  262. Continuous Glucose Monitoring, Future Products, and Update on Worldwide Artificial Pancreas Projects.
  263. Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins.
  264. Viral vector mediated continuous expression of interleukin-10 in DRG alleviates pain in type 1 diabetic animals.

    20 January 2016

  265. Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment.

    13 January 2016

  266. Day-and-Night Hybrid Closed-Loop Insulin Delivery in Adolescents With Type 1 Diabetes: A Free-Living, Randomized Clinical Trial.
  267. The role of the intestinal microbiota in type 1 diabetes mellitus.
  268. Severe epidermal nerve fiber loss in diabetic neuropathy is not reversed by long-term normoglycemia after simultaneous pancreas and kidney transplantation.
  269. Retinal Neuronal and Vascular Function in Type 1 Diabetes Adults during Glycaemic Clamps.
  270. The Effect of Long-Acting Insulin Analogs on the Risk of Cancer: A Systematic Review of Observational Studies.

    6 January 2016

  271. The role of the intestinal microbiota in type 1 diabetes mellitus.
  272. Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes.
  273. Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes Is Not Associated With Autonomic Dysfunction or Peripheral Neuropathy.
  274. Use of genetically-engineered pig donors in islet transplantation. Free full text available in HTML and PDF formats.
  275. Human pancreatic beta-like cells converted from fibroblasts. See also Insulin-producing pancreatic cells created from human skin cells.
  276. Combination Stem-Cell Transplant May Benefit Type 1 Diabetes. Free Medscape membership required.

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Last Updated: Monday January 02, 2017 14:21:24
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