According to an article written by Tim Hilchey of the New York Times News Service and printed in the August 15, 1995 edition of the Baltimore Evening Sun, researchers at the Massachusets Institute of Technology have proven that insulin can be injected using ultrasound. Dr. Robert Langer, Dr. Daniel Blankschtein and doctoral-candidate Samir Mitragotri, all of the Chemical Engineering Department, found that adding ultrasound pulses in the 20 kHz range to traditional skin patch delivery systems achieved the best results with insulin. The ultrasound pulses induce a cavitation effect within the skin, allowing insulin, which is a relatively large protein, to pass through the skin. Without the ultrasound, insulin is too large to pass.
Dr. Paul Coates, a diabetes program director at the National Institue of Diabetes, Digestive and Kidney Diseases (NIDDK), said Dr. Langer's work was a potentially valuable method of delivering insulin and other large proteins. He also said that clinical studies should begin within a year.
An August 10, 1995 press release from MIT describes the researchers work in easy-to-understand terms.
Dr. Robert Langer
Dr. Daniel Blankschtein
Last Updated: Wednesday March 16, 2005 16:45:16
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